Horn Biljana, Bao Lei, Dunham Kimberly, Stamer Mindy, Adler Stuart, Cowan Morton, Lucas Kenneth
Department of Pediatrics, Blood and Marrow Transplant Program, University of California, San Francisco, CA.
Pediatr Infect Dis J. 2009 Jan;28(1):65-7. doi: 10.1097/INF.0b013e318182026f.
We report a stem cell transplant patient with a therapy-refractory cytomegalovirus (CMV) infection who received CMV-specific T cells from his sero-negative stem cell donor. This donor received the Towne strain CMV vaccine, and T cells were expanded using monocytes pulsed with pp65 overlapping peptides. CMV DNA decreased after the CTL infusion, and CMV-specific cytotoxicity increased. This strategy could be implemented in similar situations or with persistent viremia post-transplant.
我们报告了一名干细胞移植患者，其患有治疗难治性巨细胞病毒（CMV）感染，该患者接受了来自其血清阴性干细胞供体的CMV特异性T细胞。该供体接种了Towne株CMV疫苗，并且使用用pp65重叠肽脉冲处理的单核细胞来扩增T细胞。CTL输注后CMV DNA减少，并且CMV特异性细胞毒性增加。这种策略可在类似情况下或移植后持续性病毒血症时实施。
