Corona M F, Lazzini F, Arioni C, Bertani R, de Toni T
Clinica Pediatrica, G. Gaslini, Università di Genova.
Minerva Pediatr. 1991 Jan-Feb;43(1-2):45-7.
The case of a girl with Seckel syndrome, born of an epileptic mother who was taking anticonvulsant drugs, is reported. The patient, admitted to our clinic for short stature, presented some signs of Seckel syndrome: microcephaly, a "bird headed" profile with receding chin and forehead and large beaked nose. Microcephaly and a low birth weight are present in Seckel syndrome, but also in the newborn of epileptic mothers who received anticonvulsive drugs. In the present paper the Authors questioned if the described syndrome was caused by the use of antiepileptic drugs during pregnancy, or epilepsy of the mother, or if it was casual.
本文报道了一名患有塞克尔综合征的女孩病例，其母亲为癫痫患者且正在服用抗惊厥药物。该患者因身材矮小入住我院，表现出一些塞克尔综合征的体征：小头畸形、“鸟头”面容，下巴和前额后缩，鼻子呈大喙状。小头畸形和低出生体重在塞克尔综合征中存在，但在服用抗惊厥药物的癫痫母亲所生的新生儿中也存在。在本文中，作者质疑所描述的综合征是由孕期使用抗癫痫药物引起的，还是由母亲的癫痫导致的，亦或是偶然发生的。
