Zhuang Xun, Zhu Rong-rong, Guan Huai-jin, Huang Chun-hua, Shi Wen-ping, Jiang Sheng-yang
Department of Public Health, Nantong University, Nantong 226001, China.
Zhonghua Yan Ke Za Zhi. 2008 Jun;44(6):503-6.
To understand the risk factors of primary angle-closure glaucoma.
One to one matched case-control study was conducted in this study. One hundred and ninety two PACG cases and 192 controls, matched by age and gender, were collected from Department of Ophthalmology, Affiliated Hospital of Nantong University. All of the participants were investigated for their demographic information, behavioral habits, disease history, glaucoma family history and received clinical ocular examinations. The difference between these two groups was analyzed.
Several factors, including hypertension (OR = 2.004, P = 0.009), glaucoma family history (OR = 6.726, P = 0.003), presbyopia (OR = 3.192, P = 0.031), shallow anterior chamber (OR = 12.804, P = 0.000) and high cup-to-disc ratio (OR = 9.401, P = 0.007) were associated with PACG by multiply Logistic regression. The results did not support that smoking, drinking, myopia, diabetes mellitus and blood style were related to PACG.
Follow up the populations with glaucoma family history, shallow anterior chamber or high cup-to-disc ratio are the main procedures for the decrease of incidence of PACG.
了解原发性闭角型青光眼的危险因素。
本研究采用1:1匹配的病例对照研究。从南通大学附属医院眼科收集192例原发性闭角型青光眼患者及192例年龄和性别匹配的对照。对所有参与者进行人口统计学信息、行为习惯、病史、青光眼家族史调查，并进行临床眼部检查。分析两组之间的差异。
多因素Logistic回归分析显示，高血压（OR = 2.004，P = 0.009）、青光眼家族史（OR = 6.726，P = 0.003）、老花眼（OR = 3.192，P = 0.031）、前房浅（OR = 12.804，P = 0.000）和杯盘比高（OR = 9.401，P = 0.007）与原发性闭角型青光眼相关。结果不支持吸烟、饮酒、近视、糖尿病和血型与原发性闭角型青光眼有关。
对有青光眼家族史、前房浅或杯盘比高的人群进行随访是降低原发性闭角型青光眼发病率的主要措施。
