Suk Ki Tae, Kim Chul Han, Baik Soon Koo, Kim Moon Young, Park Dong Hun, Kim Kyu Hong, Kim Jae Woo, Kim Hyun Soo, Kwon Sang Ok, Lee Dong Ki, Han Kwang Hyup, Um Soon Ho
Division of Gastroenterology & Hepatology, Department of Internal Medicine and Institute of Lifelong Health, Yonsei University Wonju College of Medicine, Wonju, South Korea.
J Clin Ultrasound. 2009 Mar-Apr;37(3):144-8. doi: 10.1002/jcu.20542.
Gallbladder wall thickening (GWT) is often observed in patients with acute hepatitis (AH). However, little is known regarding the relationship between AH and GWT. We analyzed the characteristics of GWT in patients with AH.
Between April 2002 and April 2007, 232 patients with AH underwent a sonographic examination. The clinical and laboratory findings of patients with GWT were evaluated and compared with patients without GWT. Data were recorded for the following variables: gender, age, laboratory findings, duration of symptom, presence of gallstone, and etiology of GWT.
A total of 147 (63%) patients with AH had GWT. GWT in patients with an alanine aminotransferase level more than 500 IU/l (5.2 +/- 3.4 mm) was greater than that in other patients (3.9 +/- 2.3 mm; p < 0.05). Hepatitis A virus infection (odds ratio = 3.17 [1.42-7.09]), female gender (odds ratio = 2.47 [1.34-4.56]), and an elevated total bilirubin level (odds ratio = 1.09 [1.03-1.15]) were positively associated with GWT.
The incidence of GWT in patients with AH was 63%, and there was an association with hepatitis A virus infection, female gender, and an elevated total bilirubin level.
在急性肝炎（AH）患者中常观察到胆囊壁增厚（GWT）。然而，关于AH与GWT之间的关系知之甚少。我们分析了AH患者中GWT的特征。
在2002年4月至2007年4月期间，对232例AH患者进行了超声检查。对有GWT的患者的临床和实验室检查结果进行评估，并与无GWT的患者进行比较。记录以下变量的数据：性别、年龄、实验室检查结果、症状持续时间、胆结石的存在以及GWT的病因。
共有147例（63%）AH患者有GWT。丙氨酸转氨酶水平超过500 IU/l的患者的GWT（5.2±3.4 mm）大于其他患者（3.9±2.3 mm；p<0.05）。甲型肝炎病毒感染（比值比=3.17[1.42 - 7.09]）、女性（比值比=2.47[1.34 - 4.56]）和总胆红素水平升高（比值比=1.09[1.03 - 1.15]）与GWT呈正相关。
AH患者中GWT的发生率为63%，且与甲型肝炎病毒感染、女性和总胆红素水平升高有关。
