Mahr Alfred, Belarbi Linda, Wechsler Bertrand, Jeanneret Dominique, Dhote Robin, Fain Olivier, Lhote François, Ramanoelina Jacky, Coste Joël, Guillevin Loïc
Department of Internal Medicine, Université Paris 5-René Descartes, Hôpital Cochin, Assistance Publique Hôpitaux de Paris, Paris, France.
Arthritis Rheum. 2008 Dec;58(12):3951-9. doi: 10.1002/art.24149.
To estimate the prevalence of Behçet's disease (BD) in a multiethnic population living in France, with particular focus on disease risk among immigrants.
The study was conducted in a county in the Paris metropolitan area that is home to 1,094,412 adults (ages > or =15 years), of whom 26% are of non-European ancestry. Patients with BD living in this area during 2003 were identified using 3 sources (hospitals, community physicians, and the National Health Insurance database), and diagnoses were verified using the International Study Group criteria. Standardized, year-2003 prevalence rates were computed for the overall population and for each ethnic group. Stratified prevalence rates according to age at immigration to France were calculated to investigate the relationship between age at immigration and BD risk.
Seventy-nine subjects fulfilled our search criteria. The overall prevalence per 100,000 adults was 7.1 (95% confidence interval [95% CI] 3.5-14.4), and the prevalence for populations of European, North African, and Asian ancestry was 2.4 (95% CI 0.6-7.2), 34.6 (95% CI 24.4-47.5), and 17.5 (95% CI 10.7-27.2), respectively. Within the migrant population of either North African or Asian ancestry, BD prevalences were similar for residents born in France, residents <15 years old at immigration, and residents > or =15 years old at immigration.
Our findings indicate that the prevalence of BD among immigrants of North African or Asian ancestry is significantly higher than that in the European-origin population, and comparable with rates reported from North Africa and Asia. Moreover, our results suggest that BD risk is not related to age at immigration. These findings support the hypothesis that BD has a primarily hereditary basis.
评估居住在法国的多民族人群中白塞病（BD）的患病率，特别关注移民中的疾病风险。
该研究在巴黎大都市地区的一个县进行，该县有1,094,412名成年人（年龄≥15岁），其中26%为非欧洲血统。通过三种来源（医院、社区医生和国家健康保险数据库）识别2003年期间居住在该地区的BD患者，并使用国际研究组标准对诊断进行核实。计算了2003年总体人群和每个种族群体的标准化患病率。计算了根据移民到法国时的年龄分层的患病率，以研究移民年龄与BD风险之间的关系。
79名受试者符合我们的搜索标准。每10万名成年人的总体患病率为7.1（95%置信区间[95%CI]3.5 - 14.4），欧洲、北非和亚洲血统人群的患病率分别为2.4（95%CI 0.6 - 7.2）、34.6（95%CI 24.4 - 47.5）和17.5（95%CI 10.7 - 27.2）。在北非或亚洲血统的移民人群中，法国出生的居民、移民时年龄<15岁的居民和移民时年龄≥15岁的居民的BD患病率相似。
我们的研究结果表明，北非或亚洲血统移民中的BD患病率显著高于欧洲血统人群，与北非和亚洲报告的患病率相当。此外，我们的结果表明BD风险与移民年龄无关。这些发现支持了BD主要有遗传基础的假设。
