Kreis Patricia, Barnier Jean-Vianney
CNRS, Institut de Neurobiologie Alfred Fessard-FRC2118, Laboratoire de Neurobiologie Cellulaire et Moléculaire-UPR9040, Gif sur Yvette, France.
Cell Signal. 2009 Mar;21(3):384-93. doi: 10.1016/j.cellsig.2008.11.001. Epub 2008 Nov 12.
Group I p21-activated kinases are a family of key effectors of Rac1 and Cdc42 and they regulate many aspects of cellular function, such as cytoskeleton dynamics, cell movement and cell migration, cell proliferation and differentiation, and gene expression. The three genes PAK1/2/3 are expressed in brain and recent evidence indicates their crucial roles in neuronal cell fate, in axonal guidance and neuronal polarisation, and in neuronal migration. Moreover they are implicated in neurodegenerative diseases and play an important role in synaptic plasticity, with PAK3 being specifically involved in mental retardation. The main goal of this review is to describe the molecular mechanisms that govern the different functions of group I PAK in neuronal signalling and to discuss the specific functions of each isoform.
I 型 p21 激活激酶是 Rac1 和 Cdc42 的关键效应器家族，它们调节细胞功能的许多方面，如细胞骨架动力学、细胞运动和迁移、细胞增殖与分化以及基因表达。PAK1/2/3 这三个基因在大脑中表达，最近的证据表明它们在神经元细胞命运、轴突导向和神经元极化以及神经元迁移中起关键作用。此外，它们与神经退行性疾病有关，在突触可塑性中发挥重要作用，其中 PAK3 特别涉及智力迟钝。本综述的主要目的是描述调控 I 型 PAK 在神经元信号传导中不同功能的分子机制，并讨论每种异构体的具体功能。
