Department of Cell Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan.
J Biochem. 2011 Aug;150(2):133-41. doi: 10.1093/jb/mvr080. Epub 2011 Jun 22.
The nuclear Dbf2-realted (NDR) family members are highly conserved serine/threonine protein kinases that function in concert with the Hippo signalling pathway to play crucial roles in regulation of cell proliferation and survival in non-neuronal cells. Recent studies employing a range of animal models have implicated NDR kinases as regulators of multiple aspects of development in post-mitotic neurons including progenitor proliferation, fate specification and circuit formation, all of which are crucial for neuronal functions. This review summarizes the recent advances in our understanding of the neuronal functions of NDR kinases and discusses their association with neuronal diseases.
核 Dbf2 相关（NDR）家族成员是高度保守的丝氨酸/苏氨酸蛋白激酶，与 Hippo 信号通路协同作用，在非神经元细胞中对细胞增殖和存活的调节中发挥关键作用。最近使用多种动物模型的研究表明，NDR 激酶是有丝分裂后神经元中多个发育方面的调节剂，包括祖细胞增殖、命运特化和回路形成，所有这些对神经元功能都是至关重要的。本文综述了我们对 NDR 激酶神经元功能的理解的最新进展，并讨论了它们与神经元疾病的关系。
