合成代谢类固醇的研究。VI. 氧雄龙长期给药对性腺发育不全儿童和青少年生长的影响。

Studies of anabolic steroids. VI. Effect of prolonged administration of oxandrolone on growth in children and adolescents with gonadal dysgenesis.

作者信息

Moore D C, Tattoni D S, Ruvalcaba R H, Limbeck G A, Kelley V C

出版信息

J Pediatr. 1977 Mar;90(3):462-6. doi: 10.1016/s0022-3476(77)80717-8.

PMID:190369

Abstract

Twenty-five patients with Turner Syndrome were treated with oxandrolone for six or more months. Mean growth velocity for the first year of treatment was significantly greater than pretreatment control growth velocity. Overall, there was no excessive skeletal maturation. Mean "final" height in nine XO patients (146.4 cm) was significantly greater than mean adult height of an estrogen-treated control group (140.3 cm), while that for five mosaic patients (148.2 cm) was not significantly different from a mean untreated mosaic adult height (145.2 cm).

摘要

25名特纳综合征患者接受了氧雄龙治疗六个月或更长时间。治疗第一年的平均生长速度显著高于治疗前的对照生长速度。总体而言，没有过度的骨骼成熟。9名XO患者的平均“最终”身高（146.4厘米）显著高于雌激素治疗对照组的平均成人身高（140.3厘米），而5名嵌合体患者的平均身高（148.2厘米）与未治疗的嵌合体成人平均身高（145.2厘米）没有显著差异。