Urban M D, Lee P A, Dorst J P, Plotnick L P, Migeon C J
J Pediatr. 1979 May;94(5):823-7. doi: 10.1016/s0022-3476(79)80170-5.
Long-term, low-dosage androgen treatment of patients with Turner syndrome results in more rapid growth and significantly greater adult height than in control patients who receive only estrogen for pubertal development. Seventeen patients treated with oxandrolone for one year and ten treated for two years had significantly greater growth velocities during than before treatment. Mean adult height of 25 patients treated with oxandrolone, fluoxymesterone, or both was significantly taller than the height of adult patients with Turner syndrome treated with estrogen only. Excessive skeletal maturation was not generally observed.
对特纳综合征患者进行长期低剂量雄激素治疗，与仅接受雌激素进行青春期发育的对照患者相比，可使患者生长更快，成年身高显著更高。17例接受氧雄龙治疗1年的患者和10例接受治疗2年的患者，治疗期间的生长速度明显快于治疗前。25例接受氧雄龙、氟甲睾酮或两者联合治疗的患者的平均成年身高，显著高于仅接受雌激素治疗的特纳综合征成年患者。一般未观察到骨骼过度成熟的情况。
