CREA-Research Centre for Food and Nutrition, Via Ardeatina 546, 00178 Rome, Italy.
Int J Mol Sci. 2021 Sep 7;22(18):9694. doi: 10.3390/ijms22189694.
In the era of evidence-based medicine, the randomized clinical trial corresponds to the top step in the qualitative scale of the evidence available in the literature, while small series of cases or the description of individual cases occupy the last place. However, the latter represent an important part of clinical practice and have significantly influenced the evolution of medicine, contributing significantly to the advancement of scientific knowledge. Vitamin B deficiency shares several common symptoms that affect several tissues and organs with health aliments, so its diagnosis could be unobvious for the broad array of its effects and investigation methods used. In this review, we focused our attention on some case reports related to the vitamin B deficiency associated to anemia, neurologic disorders, and hyperhomocysteinemia. B deficiency reversal is simply achieved by prompt therapy, even though it is not the same for several disorders.
在循证医学时代，随机临床试验对应于文献中可用证据的定性量表的最高步骤，而小病例系列或个别病例的描述则占据最后一位。然而，后者代表了临床实践的重要组成部分，并对医学的发展产生了重大影响，为科学知识的进步做出了重要贡献。维生素 B 缺乏症与影响多个组织和器官的健康疾病有几个共同的症状，因此由于其广泛的影响和使用的检查方法，其诊断可能并不明显。在这篇综述中，我们关注了一些与贫血、神经障碍和高同型半胱氨酸血症相关的维生素 B 缺乏症的病例报告。B 族维生素缺乏症的逆转只需通过及时治疗即可实现，尽管对于几种疾病来说并非如此。
