邻位异冰片基苯酚衍生物的抗血栓形成和抗血小板活性。
Antithrombogenic and antiplatelet activity of optho-isobornyl phenol derivative.
作者信息
Plotnikov M B, Smolyakova V I, Ivanov I S, Kuchin A V, Chukicheva I J, Krasnov E A
机构信息
Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences.
出版信息
Bull Exp Biol Med. 2008 Mar;145(3):328-30. doi: 10.1007/s10517-008-0082-x.
We studied antithrombogenic and antiplatelet properties of 4-methyl-2,6-diisobornyl phenol, a new promising compound belonging to ortho-isobornyl phenol derivatives, under conditions of intravascular thrombosis and acute cerebral ischemia. It was found that 4-methyl-2,6-diisobornyl phenol prevents intravascular thrombus formation by reducing platelet aggregation and improving antiplatelet activity of the vascular wall.
我们在血管内血栓形成和急性脑缺血的条件下，研究了4-甲基-2,6-二异冰片基苯酚（一种属于邻位异冰片基苯酚衍生物的新型有前景的化合物）的抗血栓形成和抗血小板特性。结果发现，4-甲基-2,6-二异冰片基苯酚可通过减少血小板聚集和改善血管壁的抗血小板活性来预防血管内血栓形成。
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