萜酚及其某些α-和β-衍生物的抗病毒活性评估。
Evaluation of antiviral activity of terpenophenols and some of their - and -derivatives.
作者信息
Chukicheva I Yu, Buravlev E V, Dvornikova I A, Fedorova I V, Zarubaev V V, Slita A V, Esaulkova Ya L, Kutchin A V
机构信息
Institute of Chemistry, Komi Scientific Centre, Ural Branch of the Russian Academy of Sciences, 48 ul. Pervomayskaya, 167000 Syktyvkar, Russian Federation.
St. Petersburg Pasteur Institute, 14 ul. Mira, 197101, St. Petersburg, Russian Federation.
出版信息
Russ Chem Bull. 2022;71(11):2473-2481. doi: 10.1007/s11172-022-3676-y. Epub 2022 Dec 19.
Abstract
A comparative evaluation of the antiviral activity of a number of new and previously synthesized terpenophenols and their - or -containing derivatives against the A/Puerto Rico/8/34 (H1N1) virus strain was carried out. 2-Isobornylphenol, 1,2-dihydroxy-6-isobornyl-4-methylbenzene, 2-isobornyl-1,4-benzoquinone, and N-butyl-4-hydroxy-3,5-diisobornylbenzamide showed the highest activity.
摘要
对多种新合成及先前合成的萜酚及其含衍生物针对A/波多黎各/8/34（H1N1）病毒株的抗病毒活性进行了比较评估。2-异冰片基苯酚、1,2-二羟基-6-异冰片基-4-甲基苯、2-异冰片基-1,4-苯醌和N-丁基-4-羟基-3,5-二异冰片基苯甲酰胺表现出最高活性。
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