Zhou Shui-Hong, Nie Shao-Fa, Wang Chong-Jian, Wei Sheng, Xu Yi-Hua, Li Xue-Hua, Song En-Min
Department of Epidemiology and Health Statistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2008 Jun;29(6):614-7.
To establish models to predict individual risk of essential hypertension and to evaluate and explore new forecasting methods.
To select data of 3054 community residents from an epidemiological survey and divided them into 4:1 (2438 cases and 616 cases) ratio in accordance with the balance of age and sex to filter variables, and to establish, test and evaluate the prediction models. Using artificial neural network (ANN) and logistic regression analysis to establish models while applying ROC to evaluate the prediction models.
Forecast results of the models applying to the test set proved that ANN had lower specificity but better veracity and sensitivity than logistic regression. In particular, the Youden's index of the ANN2 came up to 0.8399 which was distinctly higher than the other two models. When the area was under the ROC curve of logistic regression, the ANN, and ANN2 models equaled to 0.732 +/- 0.026, 0.900 +/- 0.014 and 0.918 +/- 0.013 respectively, which proved that the ANN model was better in the prediction about individual health risk of essential hypertension.
Our results showed that ANN method seemed better than logistic regression in terms of predicting the individual risk from hypertension thus supplied a new method to solve the forecast of individual risk.
建立预测原发性高血压个体风险的模型,并评估和探索新的预测方法。
从一项流行病学调查中选取3054名社区居民的数据,按照年龄和性别均衡的原则将其按4:1(2438例和616例)的比例划分以筛选变量,并建立、测试和评估预测模型。使用人工神经网络(ANN)和逻辑回归分析建立模型,同时应用ROC评估预测模型。
应用于测试集的模型预测结果证明,ANN的特异性较低,但准确性和敏感性优于逻辑回归。特别是,ANN2的约登指数达到0.8399,明显高于其他两个模型。当逻辑回归、ANN和ANN2模型的ROC曲线下面积分别为0.732±0.026、0.900±0.014和0.918±0.013时,证明ANN模型在预测原发性高血压个体健康风险方面更好。
我们的结果表明,在预测高血压个体风险方面,ANN方法似乎优于逻辑回归,从而为解决个体风险预测提供了一种新方法。