Yadirgi G, Marino S
Institute of Cell and Molecular Science, St. Bartholomew's and the London School of Medicine and Dentistry, London, UK.
J Pathol. 2009 Jan;217(2):242-53. doi: 10.1002/path.2480.
Stem cells are multipotent cells that can give rise to a differentiated progeny as well as self-renew. The balanced coordination of these two stem cell fates is essential for embryonic development and tissue homeostasis in the adult. Perturbed stem cell function contributes significantly to a variety of pathological conditions, eg impaired self-renewal capacity due to cellular senescence contributes to ageing, and degenerative diseases or impaired stem cell differentiation by oncogenic mutations contribute to cancer formation. This review focuses on the molecular mechanisms involved in regulating the normal function of neural stem cells in the adult mammalian brain and on the involvement of these cells in brain pathology.
干细胞是多能细胞，能够产生分化的后代并实现自我更新。这两种干细胞命运的平衡协调对于胚胎发育和成年个体的组织稳态至关重要。干细胞功能紊乱会显著导致多种病理状况，例如细胞衰老导致的自我更新能力受损会促进衰老，致癌突变导致的干细胞分化受损会促进癌症形成。本综述聚焦于成年哺乳动物大脑中调节神经干细胞正常功能的分子机制，以及这些细胞在脑部病理学中的作用。
