The School of Basic Medicine, Health Science Center, Yangtze University, Jingzhou 434023, Hubei, China.
Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore.
Aging (Albany NY). 2022 Feb 14;14(3):1562-1588. doi: 10.18632/aging.203893.
Epimedium brevicornum Maxim, a Traditional Chinese Medicine, has been used for the treatment of impotence, sinew and bone disorders, "painful impediment caused by wind-dampness," numbness, spasms, hypertension, coronary heart disease, menopausal syndrome, bronchitis, and neurasthenia for many years in China. Recent animal experimental studies indicate that icariin, a major bioactive component of epimedium may effectively treat Alzheimer's disease, cerebral ischemia, depression, Parkinson's disease, multiple sclerosis, as well as delay ageing. Our recent study also suggested that epimedium extract could exhibit radio-neuro-protective effects and prevent ionizing radiation-induced impairment of neurogenesis. This paper reviewed the pharmacodynamics of icariin in treating different neurodegenerative and neuropsychiatric diseases, ageing, and radiation-induced brain damage. The relevant molecular mechanisms and its anti-neuroinflammatory, anti-apoptotic, anti-oxidant, as well as pro-neurogenesis roles were also discussed.
朝凤草（Epimedium brevicornum Maxim）是一种中药，在中国已经被用于治疗阳痿、筋骨疾病、“风痹痛”、麻木、痉挛、高血压、冠心病、更年期综合征、支气管炎和神经衰弱多年。最近的动物实验研究表明，淫羊藿的主要生物活性成分朝凤草苷可能有效地治疗阿尔茨海默病、脑缺血、抑郁症、帕金森病、多发性硬化症以及延缓衰老。我们最近的研究还表明，淫羊藿提取物可以表现出放射神经保护作用，防止电离辐射引起的神经发生损伤。本文综述了朝凤草苷治疗不同神经退行性和神经精神疾病、衰老以及辐射诱导脑损伤的药效学。还讨论了相关的分子机制以及其抗神经炎症、抗细胞凋亡、抗氧化和促进神经发生的作用。
