Yackobovitch-Gavan Michal, Golan Moria, Valevski Avi, Kreitler Shulamit, Bachar Eytan, Lieblich Amia, Mitrani Edith, Weizman Abraham, Stein Daniel
School of Nutritional Sciences, Faculty of Agricultural, Food, and Environmental Quality Sciences, Rehovot.
Int J Eat Disord. 2009 May;42(4):306-17. doi: 10.1002/eat.20624.
To identify factors influencing the course of anorexia nervosa (AN) over time.
Former female patients with AN (36 remitted and 24 nonremitted) and 31 healthy females responded to standardized interviews and self-rating questionnaires. Remitted patients maintained normal eating, normal weight, and regular menses for the past 12 months. Patients not fulfilling these criteria were considered nonremitted.
Using logistic regression, we identified that number of hospitalizations, duration of ambulatory treatment, past vegetarianism, past anxiety, and childhood sexual abuse differentiated remitted from nonremitted patients, predicting nonremission. A similar analysis identified that elevated follow-up vegetarianism and eating-related concerns and lower body mass index (BMI) differentiated remitted from nonremitted patients, contributing to nonremission. Univariate analyses identified that remitted patients had elevated anxiety and eating-related obsessionality compared with the controls, suggesting these variables to potentially predispose to AN.
Elevated anxiety and eating-related obsessionality may increase the risk for the development of AN and for nonremission.
确定随时间推移影响神经性厌食症（AN）病程的因素。
曾患AN的女性患者（36例缓解者和24例未缓解者）以及31名健康女性对标准化访谈和自评问卷进行了作答。缓解患者在过去12个月保持正常饮食、正常体重和规律月经。未达这些标准的患者被视为未缓解。
通过逻辑回归分析，我们发现住院次数、门诊治疗时长、既往素食习惯、既往焦虑症史以及童年期性虐待可区分缓解患者与未缓解患者，并可预测未缓解情况。类似分析发现，随访期素食习惯增加、饮食相关担忧以及较低的体重指数（BMI）可区分缓解患者与未缓解患者，导致未缓解。单因素分析发现，与对照组相比，缓解患者焦虑症及饮食相关强迫观念增加，提示这些变量可能是AN的潜在易感因素。
焦虑症及饮食相关强迫观念增加可能会增加AN发病及未缓解的风险。
