Efficacy and safety of transdermal fentanyl for treatment of oral mucositis pain caused by chemotherapy.

作者信息

Cai Qingqing, Huang Huiqiang, Sun Xiaofei, Xia Zhongjun, Li Yuhong, Lin Xubin, Guo Ying

机构信息

Sun Yat-sen University, Cancer Center, Guangzhou, Department of Medical Oncology, State Key Laboratory of Oncology in Southern China, 651 E. Dongfeng Road, Guangzhou, 510060, PR China.

出版信息

Expert Opin Pharmacother. 2008 Dec;9(18):3137-44. doi: 10.1517/14656560802504508.

BACKGROUND/OBJECTIVE: We investigated the efficacy and safety of transdermal fentanyl for severe mucositis pain caused by chemotherapy.

METHODS

Thirty-two patients who had moderate to severe pain using the Numeric Rating Scale (NRS) were enrolled in this study. The analgesic effect, quality of life and side effects were evaluated after the administration of transdermal fentanyl.

RESULTS

The median NRS score was reduced from 6 (range 4 - 9) before treatment to 4 (range 0 - 9), 2.5 (range 0 - 8), 2 (range 0 - 8), 2 (range 0 - 6) and 0 (range 0 - 5) on days 3, 5, 7, 10 and 15, respectively, after treatment (p < 0.001). The patients' quality of life also improved significantly (p < 0.01). The side effects of treatment were mild, and disappeared within several days.

CONCLUSIONS

Transdermal fentanyl is an effective, convenient and well-tolerated treatment for severe mucositis pain caused by chemotherapy that can improve patients' quality of life.