Department of Physiology, Faculty of Medicine, Jagiellonian University Medical College, Grzegórzecka 16 St., 31-531 Krakow, Poland.
Int J Mol Sci. 2019 Mar 27;20(7):1534. doi: 10.3390/ijms20071534.
Chemotherapy and/or head and neck radiotherapy are frequently associated with oral mucositis. Oral pain, odynophagia and dysphagia, opioid use, weight loss, dehydration, systemic infection, hospitalization and introduction of a feeding tube should be mentioned as the main determinated effect of oral mucositis. Oral mucositis leads to a decreased quality of life and an increase in treatment costs. Moreover, oral mucositis is a life-threatening disease. In addition to its own direct life-threatening consequences, it can also lead to a reduced survival due to the discontinuation or dose reduction of anti-neoplasm therapy. There are numerous strategies for the prevention or treatment of oral mucositis; however, their effectiveness is limited and does not correspond to expectations. This review is focused on the ghrelin and obestatin as potentially useful candidates for the prevention and treatment of chemo- or/and radiotherapy-induced oral mucositis.
化疗和/或头颈部放疗常伴有口腔黏膜炎。口腔疼痛、吞咽困难、阿片类药物使用、体重减轻、脱水、全身感染、住院和插入喂养管应被视为口腔黏膜炎的主要决定因素。口腔黏膜炎导致生活质量下降和治疗费用增加。此外，口腔黏膜炎是一种危及生命的疾病。除了其自身直接危及生命的后果外，由于抗肿瘤治疗的中断或剂量减少，也会导致生存率降低。有许多预防或治疗口腔黏膜炎的策略；然而，它们的效果有限，并不符合预期。本综述重点介绍胃饥饿素和肥胖抑制素作为预防和治疗化疗和/或放疗引起的口腔黏膜炎的潜在有用候选药物。
