Mula Marco, Schmitz Bettina, Sander Josemir W
Amedeo Avogadro University, Department of Clinical & Experimental Medicine, Section of Neurology, Novara, Italy.
Expert Opin Pharmacother. 2008 Dec;9(18):3159-68. doi: 10.1517/14656560802587024.
Comorbid mood disorders may affect quality of life in people with epilepsy.
To review available data on the use of antidepressant drugs in epilepsy taking into account major concerns that may be encountered by clinicians, namely pharmacokinetic interactions with antiepileptic medications and seizure aggravation.
Data on pharmacotherapy of depression in epilepsy are limited with no controlled clinical trials investigating efficacy and safety of antidepressants. Data on seizure risk come from psychiatric samples, thus limiting the general applicability to people with epilepsy.
Antidepressant drug doses need to be used and adjusted according to individual clinical needs. Within the therapeutic range, the incidence of seizures in psychiatric populations is low for most antidepressants.
共病情绪障碍可能会影响癫痫患者的生活质量。
考虑临床医生可能遇到的主要问题，即与抗癫痫药物的药代动力学相互作用和癫痫发作加重，回顾有关抗抑郁药物在癫痫中应用的现有数据。
癫痫患者抑郁症药物治疗的数据有限，尚无对照临床试验研究抗抑郁药的疗效和安全性。癫痫发作风险的数据来自精神科样本，因此限制了其对癫痫患者的普遍适用性。
抗抑郁药物剂量需要根据个体临床需求使用和调整。在治疗范围内，大多数抗抑郁药在精神科人群中的癫痫发作发生率较低。
