Amano H, Nagai Y, Ishikawa O
Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Clin Exp Dermatol. 2009 Jul;34(5):e14-7. doi: 10.1111/j.1365-2230.2008.02975.x. Epub 2009 Nov 24.
We report a 29-year-old woman with a 15-year history of recurrent pruritic urticarial erythemas. The individual lesions lasted for > 24 h, and antihistaminic agents were not effective. Histological examination of a skin biopsy revealed interstitial oedema of the dermis and perivascular infiltration of numerous eosinophils without vasculitis. No internal organ involvement or peripheral blood eosinophilia was present. A diagnosis of persistent urticaria was made and the patient was successfully treated with oral corticosteroid therapy. Persistent urticaria has been described as an unusual reaction that lasts longer than typical urticaria. It is effectively treated with corticosteroids, but not with antihistaminic agents. In order to choose the most effective treatment, persistent urticaria should be recognized as a different clinical condition from typical urticaria.
我们报告了一名29岁女性，有15年复发性瘙痒性荨麻疹性红斑病史。单个皮疹持续超过24小时，抗组胺药治疗无效。皮肤活检的组织学检查显示真皮间质水肿和大量嗜酸性粒细胞血管周围浸润，无血管炎。未出现内脏器官受累或外周血嗜酸性粒细胞增多。诊断为持久性荨麻疹，患者接受口服糖皮质激素治疗后获得成功。持久性荨麻疹被描述为一种持续时间长于典型荨麻疹的异常反应。糖皮质激素治疗有效，但抗组胺药治疗无效。为了选择最有效的治疗方法，应将持久性荨麻疹视为一种与典型荨麻疹不同的临床病症。
