Horwitz David A
Department of Medicine, Division of Rheumatology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA.
Arthritis Res Ther. 2008;10(6):227. doi: 10.1186/ar2511. Epub 2008 Nov 14.
Regulatory/suppressor T cells (Tregs) maintain immunologic homeo-stasis and prevent autoimmunity. In this article, past studies and recent studies of Tregs in mouse models for lupus and of human systemic lupus erythematosus are reviewed concentrating on CD4+CD25+Foxp3+ Tregs. These cells consist of thymus-derived, natural Tregs and peripherally induced Tregs that are similar phenotypically and functionally. These Tregs are decreased in young lupus-prone mice, but are present in normal numbers in mice with established disease. In humans, most workers report CD4+Tregs are decreased in subjects with active systemic lupus erythematosus, but the cells increase with treatment and clinical improvement. The role of immunogenic and tolerogenic dendritic cells in controlling Tregs is discussed, along with new strategies to normalize Treg function in systemic lupus erythematosus.
调节性/抑制性T细胞（Tregs）维持免疫稳态并预防自身免疫。在本文中，我们回顾了过去和近期关于Tregs在狼疮小鼠模型及人类系统性红斑狼疮中的研究，重点关注CD4+CD25+Foxp3+ Tregs。这些细胞包括胸腺来源的天然Tregs和外周诱导的Tregs，它们在表型和功能上相似。在易患狼疮的年轻小鼠中，这些Tregs数量减少，但在已患疾病的小鼠中数量正常。在人类中，大多数研究人员报告称，活动性系统性红斑狼疮患者的CD4+Tregs数量减少，但随着治疗和临床改善，这些细胞数量会增加。本文还讨论了免疫原性和耐受性树突状细胞在控制Tregs中的作用，以及使系统性红斑狼疮中Treg功能正常化的新策略。
