Grant J, Denne S C
Department of Pediatrics, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis 46202-5210.
J Pediatr. 1991 Jun;118(6):928-32. doi: 10.1016/s0022-3476(05)82213-9.
The purpose of this study was to examine whether premature infants have higher rates of energy expenditure and diet-induced thermogenesis during intermittent feeding compared with continuous feeding. Using open-circuit respiratory calorimetry, we measured energy expenditure in 11 premature newborn infants on 2 successive days for 5 to 7 hours during and after either intermittent or continuous feeding. Infants were fed the same quantity of formula each day, either for 5 minutes or by continuous drip for 2 to 3 hours. The order of feeding type was randomized. No response of diet-induced thermogenesis to continuous feeding was found, whereas a peak increase of 15% over baseline was observed after intermittent feeding. Overall energy expenditure during the study period was significantly greater after intermittent compared with continuous feeding (2.18 +/- 0.07 kcal/kg per hour vs 2.09 +/- 0.05 kcal/kg per hour; p less than 0.05). Thus there was a mean 4% difference (range up to 17%) in energy expenditure between the two feeding modes. These results are similar to those obtained with adults and support the concept of the increased energy efficiency of continuous feeding. Further study will be necessary to document whether the increased energy efficiency provided by continuous feeding may be clinically significant.
本研究的目的是检验与持续喂养相比，早产儿在间歇喂养期间是否具有更高的能量消耗率和饮食诱导产热。使用开路呼吸热量测定法，我们在11名早产新生儿连续2天的间歇喂养期间及之后以及持续喂养期间及之后，测量了5至7小时的能量消耗。婴儿每天喂食相同量的配方奶，要么喂食5分钟，要么持续滴注2至3小时。喂养类型的顺序是随机的。未发现饮食诱导产热对持续喂养有反应，而在间歇喂养后观察到比基线水平峰值增加15%。与持续喂养相比，研究期间间歇喂养后的总体能量消耗显著更高（2.18±0.07千卡/千克每小时对2.09±0.05千卡/千克每小时；p<0.05）。因此，两种喂养方式之间的能量消耗平均相差4%（范围高达17%）。这些结果与在成人中获得的结果相似，并支持持续喂养能量效率提高的概念。有必要进行进一步研究以证明持续喂养所提供的能量效率提高在临床上是否具有重要意义。
