同卵双胞胎中的不同类型肠闭锁

Different types of intestinal atresia in identical twins.

作者信息

De Grazia Enrico, Di Pace Maria Rita, Caruso Anna Maria, Catalano Pieralba, Cimador Marcello

机构信息

Pediatric Surgical Unit, Department for Mother and Child Care, Università di Palermo, 90142 Palermo, Italy.

出版信息

J Pediatr Surg. 2008 Dec;43(12):2301-4. doi: 10.1016/j.jpedsurg.2008.08.068.

DOI:10.1016/j.jpedsurg.2008.08.068

PMID:19040960

Abstract

The authors present a previously unreported association of different types of intestinal atresia in identical low-birth-weight twins. Both babies were affected by duodenal atresia, associated in the first case with a complete mucosal duodenal membrane and in the second one with an "apple-peel" jejunal atresia. These occurrences may suggest that they were either the consequence of linkage of 2 genes or a pleiotropic expression of a single gene responsible for such rare conditions.

摘要

作者报告了一对同卵低体重双胞胎中不同类型肠道闭锁的一种此前未被报道的关联情况。两个婴儿均患有十二指肠闭锁，第一例伴有完整的十二指肠黏膜隔膜，第二例伴有“苹果皮”样空肠闭锁。这些情况可能表明，它们要么是两个基因连锁的结果，要么是单个基因的多效性表达导致了这种罕见病症。