Jun John Y, Manni Andrea
Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Otolaryngol Clin North Am. 2008 Dec;41(6):1241-60, xi-xii. doi: 10.1016/j.otc.2008.05.005.
This article presents an overview of medical management of persistent or recurrent differentiated thyroid cancer, in particular focusing on monitoring strategy and treatment plans. Most patients with differentiated thyroid carcinoma can be successfully rendered to be free of disease with initial treatments, and those with persistent or recurrent disease can still expect long-term survival when they are monitored properly and treated accordingly. Along with serum thyroglobulin, neck ultrasonography, and radioactive iodine whole-body scans, the use of cross-sectional imaging studies and (18F) fluoro-2-deoxy-D-glucose-positron emission tomography have facilitated the effort in localizing lesions and traditional treatments can be implemented effectively. For disease resistant to conventional therapies, there are new treatment modalities emerging and being tested, including several agents targeting specific signaling pathways, each of which may offer the potential remedy.
本文概述了持续性或复发性分化型甲状腺癌的医学管理，尤其着重于监测策略和治疗计划。大多数分化型甲状腺癌患者通过初始治疗可成功实现无病状态，而那些患有持续性或复发性疾病的患者，若得到妥善监测并相应治疗，仍有望长期存活。除血清甲状腺球蛋白、颈部超声检查和放射性碘全身扫描外，横断面成像研究及（18F）氟-2-脱氧-D-葡萄糖正电子发射断层扫描的应用有助于定位病变，从而能有效实施传统治疗。对于对传统疗法耐药的疾病，正在涌现并进行测试的新治疗方式包括几种针对特定信号通路的药物，每种药物都可能提供潜在的治疗方法。
