Keegan R D, Gleed R D, Sanders E A, Seaman G C, Wertz E M, Short C E
Department of Clinical Sciences, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853.
Vet Surg. 1991 Mar-Apr;20(2):148-52. doi: 10.1111/j.1532-950x.1991.tb00325.x.
Clenbuterol (0.8 microgram/kg intravenously) was administered to 10 anesthetized horses with an abnormally low PaO2 (less than 90 mm Hg) despite controlled ventilation with an oxygen-rich gas mixture. Results were compared with those from 10 controls to which no clenbuterol was given and in which conventional methods to increase PaO2 were ongoing. Horses treated with clenbuterol had higher PaO2 values for at least 90 minutes. Clenbuterol was associated with increased heart rate and profuse sweating. Clenbuterol can be administered intravenously to increase the PaO2 of mechanically ventilated horses that have low arterial oxygen tension while under inhalation anesthesia. Further studies are warranted to define more precisely the circumstances under which clenbuterol may be used safely.
对10匹麻醉的马静脉注射克仑特罗（0.8微克/千克），这些马尽管使用富氧气体混合物进行控制通气，但动脉血氧分压（PaO2）仍异常低（低于90毫米汞柱）。将结果与10匹未注射克仑特罗且正在采用传统方法提高PaO2的对照马的结果进行比较。接受克仑特罗治疗的马在至少90分钟内PaO2值更高。克仑特罗与心率加快和大量出汗有关。在吸入麻醉下，可静脉注射克仑特罗以提高动脉血氧张力低的机械通气马的PaO2。有必要进行进一步研究以更精确地确定安全使用克仑特罗的情况。
