Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL.
Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL.
J Equine Vet Sci. 2022 Jun;113:103944. doi: 10.1016/j.jevs.2022.103944. Epub 2022 Apr 8.
Impairment of oxygen uptake can occur during general anesthesia in horses resulting in hypoxemia. Multiple treatments have been investigated for correction of hypoxemia with varying levels of success. In clinical trials, albuterol, a short-acting β adrenergic agonist, improved arterial oxygen partial pressure (PaO) in anesthetized horses unresponsive to adjustments in mechanical ventilation and administration of positive inotropic drugs. However, controlled studies comparing the magnitude of change and duration of effect of albuterol on PaO in healthy, nonhypoxemic anesthetized horses are lacking. In a prospective study, 14 horses were anesthetized and received a FiO of 0.5 (n = 7) or > 0.95 (n = 7). Horses were maintained on isoflurane and mechanically ventilated. After 15 minutes, baseline PaO was determined. Within each FiO group, five horses were administered inhaled albuterol (2 µg/kg) and two horses received no treatment. At 10, 20, 30, and 40 minutes after baseline, PaO was measured. Data for horses that received albuterol were analyzed with repeated measures analysis of variance with significance at P < .05. Horses that received albuterol had an increase in PaO for at least 40 minutes after baseline. Albuterol administered via inhalation, was associated with an increased PaO of at least 40 minutes compared to baseline in healthy, nonhypoxemic horses undergoing anesthesia at similar depth, using a FiO of 0.5 and > 0.95. Side effects were mild and consisted of increased heart rate and sweating. Albuterol administered at 2 μg/kg via inhalation may be useful for increasing PaO in anesthetized horses.
在马的全身麻醉过程中，氧气摄取能力可能会受损，导致低氧血症。已经研究了多种治疗方法来纠正低氧血症，但成功率各不相同。在临床试验中，短效β肾上腺素能激动剂沙丁胺醇可改善对机械通气调整和正性肌力药物治疗无反应的麻醉马的动脉氧分压（PaO）。然而，缺乏比较健康、非低氧血症麻醉马中沙丁胺醇对 PaO 影响程度和持续时间的对照研究。在一项前瞻性研究中，14 匹马被麻醉并接受 FiO 为 0.5（n=7）或>0.95（n=7）。马接受异氟醚维持麻醉并进行机械通气。15 分钟后，确定基础 PaO。在每个 FiO 组中，5 匹马给予吸入沙丁胺醇（2μg/kg），2 匹马未接受治疗。在基线后 10、20、30 和 40 分钟测量 PaO。接受沙丁胺醇的马的数据用重复测量方差分析进行分析，P<0.05 时有统计学意义。接受沙丁胺醇的马在基线后至少 40 分钟内 PaO 增加。与基线相比，在接受类似深度麻醉、FiO 为 0.5 和>0.95 的健康、非低氧血症马中，吸入沙丁胺醇可使 PaO 至少增加 40 分钟，副作用轻微，包括心率加快和出汗。吸入 2μg/kg 的沙丁胺醇可能有助于增加麻醉马的 PaO。
