Spence G, Phillips S, Campion C, Brooks R, Rushton N
Orthopaedic Research Unit, University of Cambridge, Addenbrookes Hospital, Cambridge, England.
J Bone Joint Surg Br. 2008 Dec;90(12):1635-40. doi: 10.1302/0301-620X.90B12.20931.
Carbonate-substituted hydroxyapatite (CHA) is more osteoconductive and more resorbable than hydroxyapatite (HA), but the underlying mode of its action is unclear. We hypothesised that increased resorption of the ceramic by osteoclasts might subsequently upregulate osteoblasts by a coupling mechanism, and sought to test this in a large animal model. Defects were created in both the lateral femoral condyles of 12 adult sheep. Six were implanted with CHA granules bilaterally, and six with HA. Six of the animals in each group received the bisphosphonate zoledronate (0.05 mg/kg), which inhibits the function of osteoclasts, intra-operatively. After six weeks bony ingrowth was greater in the CHA implants than in HA, but not in the animals given zoledronate. Functional osteoclasts are necessary for the enhanced osteoconduction seen in CHA compared with HA.
碳酸根取代的羟基磷灰石（CHA）比羟基磷灰石（HA）具有更高的骨传导性和更高的可吸收性，但其作用的潜在模式尚不清楚。我们推测破骨细胞对陶瓷的吸收增加可能随后通过耦合机制上调成骨细胞，并试图在大型动物模型中对此进行测试。在12只成年绵羊的双侧股骨外侧髁制造缺损。6只双侧植入CHA颗粒，6只植入HA。每组中有6只动物在术中接受双膦酸盐唑来膦酸（0.05mg/kg），其抑制破骨细胞的功能。六周后，CHA植入物中的骨向内生长比HA植入物中的更大，但在给予唑来膦酸的动物中则不然。与HA相比，功能性破骨细胞是CHA中增强骨传导所必需的。
