Dingle Kaeleen, Alati Rosa, Clavarino Alexandra, Najman Jake M, Williams Gail M
School of Population Health, University of Queensland, Herston Road, Herston, QLD 4006, Australia.
Br J Psychiatry. 2008 Dec;193(6):455-60. doi: 10.1192/bjp.bp.108.055079.
Recent evidence has linked induced abortion with later adverse psychiatric outcomes in young women.
To examine whether abortion or miscarriage are associated with subsequent psychiatric and substance use disorders.
A sample (n=1223) of women from a cohort born between 1981 and 1984 in Australia were assessed at 21 years for psychiatric and substance use disorders and lifetime pregnancy histories.
Young women reporting a pregnancy loss had nearly three times the odds of experiencing a lifetime illicit drug disorder (excluding cannabis): abortion odds ratio (OR)=3.6 (95% CI 2.0-6.7) and miscarriage OR=2.6 (95% CI 1.2-5.4). Abortion was associated with alcohol use disorder (OR=2.1, 95% CI 1.3-3.5) and 12-month depression (OR=1.9, 95% CI 1.1-3.1).
These findings add to the growing body of evidence suggesting that pregnancy loss per se, whether abortion or miscarriage, increases the risk of a range of substance use disorders and affective disorders in young women.
近期证据表明，人工流产与年轻女性日后出现的不良精神状况有关。
研究人工流产或自然流产是否与后续的精神疾病及物质使用障碍相关。
对澳大利亚1981年至1984年间出生的队列中的1223名女性进行抽样，在她们21岁时评估其精神疾病、物质使用障碍及终生妊娠史。
报告有妊娠丢失的年轻女性出现终生非法药物使用障碍（不包括大麻）的几率几乎是三倍：人工流产的优势比（OR）=3.6（95%置信区间2.0 - 6.7），自然流产的OR = 2.6（95%置信区间1.2 - 5.4）。人工流产与酒精使用障碍（OR = 2.1，95%置信区间1.3 - 3.5）及12个月内的抑郁（OR = 1.9，95%置信区间1.1 - 3.1）相关。
这些发现进一步证明，妊娠丢失本身，无论是人工流产还是自然流产，都会增加年轻女性出现一系列物质使用障碍和情感障碍的风险。
