Redemann-Fibi B, Schuermann M, Müller R
Institut für Molekularbiologie und Tumorforschung (IMT), Phillips-Universität Marburg, Federal Republic of Germany.
Differentiation. 1991 Feb;46(1):43-9. doi: 10.1111/j.1432-0436.1991.tb00864.x.
The product of the fos-related fosB gene shares many properties with c-Fos such as inducibility by growth factors, complex formation with members of the Jun family and cooperative binding with Jun to the TPA response element (TRE). To investigate whether in contrast to these functional similarities, the two genes might be differentially regulated, we have analysed the expression of fosB during mouse development by in situ hybridization. A spatially restricted accumulation of fosB mRNA in the visceral yolk sac and the nervous system was observed during late gestation. The highest levels of fosB mRNA were found in the cortex and the dorsal columns of the spinal cord. Moreover, stage-specific expression was seen in sensory organs such as retina and vibrissae, where the levels of fosB RNA either increased (retina) or decreased (vibrissae) between days 15 and 18. Our results suggest that fosB may have a specific function in the development of ectoderm-derived tissues. Expression of fosB during prenatal development differs markedly from the known expression pattern of c-fos, pointing to different tissue-specific functions for c-fos and fosB.
与fos相关的fosB基因产物与c-Fos具有许多共同特性，如可被生长因子诱导、与Jun家族成员形成复合物以及与Jun协同结合至佛波酯反应元件（TPA反应元件）。为了研究与这些功能相似性相反，这两个基因是否可能受到不同的调控，我们通过原位杂交分析了fosB在小鼠发育过程中的表达。在妊娠后期，在内脏卵黄囊和神经系统中观察到fosB mRNA存在空间受限的积累。在脊髓的皮质和背柱中发现了最高水平的fosB mRNA。此外，在视网膜和触须等感觉器官中观察到了阶段特异性表达，在第15天至18天之间，fosB RNA水平在视网膜中升高而在触须中降低。我们的结果表明，fosB可能在外胚层衍生组织的发育中具有特定功能。产前发育期间fosB的表达与已知的c-fos表达模式明显不同，这表明c-fos和fosB具有不同的组织特异性功能。
