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Immunology. 1991 May;73(1):44-51.
2
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9
Natural killer cells play a role in MHC class I in vivo induction in tumor cells that are MHC negative in vitro.自然杀伤细胞在体外MHC阴性的肿瘤细胞的体内MHC I类诱导中发挥作用。
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Lytic susceptibility of target cells to cytotoxic T cells is determined by their constitutive major histocompatibility complex class I antigen expression and cytokine-induced activation status.靶细胞对细胞毒性T细胞的溶解敏感性取决于其组成性主要组织相容性复合体I类抗原表达和细胞因子诱导的激活状态。
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RB mutation and RAS overexpression induce resistance to NK cell-mediated cytotoxicity in glioma cells.RB基因变异和RAS过表达导致胶质瘤细胞对自然杀伤细胞介导的细胞毒性产生抗性。
Cancer Cell Int. 2015 Jun 5;15:57. doi: 10.1186/s12935-015-0209-x. eCollection 2015.
2
Identification of a novel signal transduction surface molecule on human cytotoxic lymphocytes.人类细胞毒性淋巴细胞上一种新型信号转导表面分子的鉴定。
J Exp Med. 1993 Oct 1;178(4):1397-406. doi: 10.1084/jem.178.4.1397.
3
Protection against natural killer cells by interferon-gamma treatment of K562 cells cannot be explained by augmented major histocompatibility complex class I expression.通过干扰素-γ处理K562细胞来抵御自然杀伤细胞的作用，无法用主要组织相容性复合体I类分子表达增强来解释。
Immunology. 1994 Sep;83(1):75-80.

本文引用的文献

1
Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens.分泌针对小鼠H-2和Ia抗原的单克隆抗体的杂交瘤细胞系。
J Immunol. 1980 Feb;124(2):533-40.
2
Monoclonal antibodies to mouse MHC antigens. III. Hybridoma antibodies reacting to antigens of the H-2b haplotype reveal genetic control of isotype expression.抗小鼠主要组织相容性复合体（MHC）抗原的单克隆抗体。III. 与H-2b单倍型抗原发生反应的杂交瘤抗体揭示了同种型表达的遗传控制。
J Immunol. 1981 Jan;126(1):317-21.
3
Quantitative studies of natural immunity to solid tumours in rats. Persistence of natural immunity throughout reproductive life, and absence of suppressor cells in infant rats.大鼠对实体瘤天然免疫的定量研究。整个生殖期天然免疫的持续性，以及幼鼠中抑制细胞的缺失。
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Immunogenetics. 1980;11(5):441-9. doi: 10.1007/BF01567813.
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Lymphokine-driven "differentiation" of cytotoxic T-cell clones into cells with NK-like specificity: correlations with display of membrane macromolecules.淋巴因子驱动细胞毒性T细胞克隆“分化”为具有自然杀伤细胞样特异性的细胞：与膜大分子表达的相关性
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Murine H-2Dd-reactive monoclonal antibodies recognize shared antigenic determinant(s) on human HLA-B7 or HLA-B27 molecules or both.鼠源H-2Dd反应性单克隆抗体可识别人类HLA - B7或HLA - B27分子或两者上的共同抗原决定簇。
Immunogenetics. 1983;17(4):357-70. doi: 10.1007/BF00372455.
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Exon shuffling: mapping polymorphic determinants on hybrid mouse transplantation antigens.外显子改组：在杂种小鼠移植抗原上定位多态性决定簇
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Cytolytic T cells recognize the two amino-terminal domains of H-2 K antigens in tandem in influenza A infected cells.细胞溶解性T细胞在甲型流感病毒感染的细胞中串联识别H-2 K抗原的两个氨基末端结构域。
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10
Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defence strategy.对H-2缺陷型淋巴瘤变体的选择性排斥表明存在替代免疫防御策略。
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转染的MHC I类基因对自然杀伤细胞敏感性的影响。

The effect of transfected MHC class I genes on sensitivity to natural killer cells.

作者信息

Holscher M, Givan A L, Brooks C G

机构信息

Department of Immunology, The Medical School, Newcastle upon Tyne.

出版信息

Immunology. 1991 May;73(1):44-51.

PMID:1904402
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1384516/
Abstract

To test the hypothesis that major histocompatibility complex (MHC) molecules protect target cells from lysis by natural killer cells (NKC), we transfected the MHC- B16 melanoma line F10 with the class I genes encoding Dd, Kb, and Kk. Only low levels of Dd expression could be obtained and there was no protection against NKC. By contrast, Kb and Kk transfectants were obtained which displayed significant resistance to NKC, and with the latter transfectants resistance was clearly related to the level of transgene expression. Various mutants of the F10 line with altered patterns of MHC expression were also obtained. These mutant lines provided evidence that (i) the Db molecule is also capable of inducing resistance to NKC and (ii) high MHC class I expression does not by itself guarantee lowered susceptibility to NKC.

摘要

为了验证主要组织相容性复合体（MHC）分子可保护靶细胞免受自然杀伤细胞（NKC）裂解这一假说，我们用编码Dd、Kb和Kk的I类基因转染了MHC - B16黑色素瘤细胞系F10。仅获得了低水平的Dd表达，且未观察到对NKC的保护作用。相比之下，获得了对NKC具有显著抗性的Kb和Kk转染细胞，对于后者，抗性明显与转基因表达水平相关。还获得了具有改变的MHC表达模式的F10细胞系的各种突变体。这些突变细胞系提供了以下证据：（i）Db分子也能够诱导对NKC的抗性；（ii）高MHC I类表达本身并不能保证对NKC的易感性降低。