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c-Myc的过表达抑制了小鼠红白血病细胞中β-珠蛋白染色质上特定DNase I超敏位点的出现。

Overexpression of c-Myc inhibits the appearance of a specific DNase I hypersensitive site in the beta-globin chromatin in murine erythroleukemia cells.

作者信息

Takada S, Obinata M

机构信息

Department of Cell Biology, Research Institute for Tuberculosis and Cancer, Tohoku University, Sendai.

出版信息

Jpn J Cancer Res. 1991 Apr;82(4):376-9. doi: 10.1111/j.1349-7006.1991.tb01858.x.

DOI:10.1111/j.1349-7006.1991.tb01858.x
PMID:1904416
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5918440/
Abstract

To investigate the molecular mechanism of regulation of differentiation by c-Myc, we examined the acquisition of DNase I hypersensitivity by beta-globin chromatin in an MEL cell transformant (38-2) in which the c-myc gene was placed under the control of a metallothionein gene promoter. Of the three DNase I hypersensitive sites around the beta-globin gene which were detected in MEL cells after DMSO treatment, the appearance of a specific DNase I hypersensitive site near the promoter was greatly reduced by the overexpression of c-Myc. This result suggests that c-Myc regulates beta-globin expression by interfering with the establishment of an active chromatin conformation around the beta-globin gene.

摘要

为了研究c-Myc调控分化的分子机制，我们检测了金属硫蛋白基因启动子控制下的c-myc基因的MEL细胞转化体（38-2）中β-珠蛋白染色质对DNase I超敏性的获得情况。在DMSO处理后的MEL细胞中检测到的β-珠蛋白基因周围的三个DNase I超敏位点中，启动子附近一个特定的DNase I超敏位点的出现因c-Myc的过表达而大大减少。这一结果表明，c-Myc通过干扰β-珠蛋白基因周围活性染色质构象的建立来调控β-珠蛋白的表达。

相似文献

1
Overexpression of c-Myc inhibits the appearance of a specific DNase I hypersensitive site in the beta-globin chromatin in murine erythroleukemia cells.c-Myc的过表达抑制了小鼠红白血病细胞中β-珠蛋白染色质上特定DNase I超敏位点的出现。
Jpn J Cancer Res. 1991 Apr;82(4):376-9. doi: 10.1111/j.1349-7006.1991.tb01858.x.
2
DNase I hypersensitive sites of globin genes of uninduced Friend erythroleukemia cells and changes during induction with dimethyl sulfoxide.未诱导的Friend红白血病细胞珠蛋白基因的DNA酶I超敏位点及二甲基亚砜诱导过程中的变化。
J Biol Chem. 1983 Sep 10;258(17):10622-8.
3
Sequential alterations in globin gene chromatin structure during erythroleukemia cell differentiation.红白血病细胞分化过程中珠蛋白基因染色质结构的序列改变。
J Biol Chem. 1985 Mar 10;260(5):3035-40.
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Murine erythroleukemia cell differentiation: DNase I hypersensitivity and DNA methylation near the globin genes.小鼠红白血病细胞分化：珠蛋白基因附近的脱氧核糖核酸酶I超敏反应和DNA甲基化
Proc Natl Acad Sci U S A. 1982 Feb;79(4):1180-4. doi: 10.1073/pnas.79.4.1180.
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c-Myc interferes with the commitment to differentiation of murine erythroleukemia cells at a reversible point.c-Myc在一个可逆点干扰小鼠红白血病细胞的分化进程。
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Alterations in globin gene chromatin conformation during murine erythroleukemia cell differentiation.小鼠红白血病细胞分化过程中珠蛋白基因染色质构象的改变。
J Biol Chem. 1984 Apr 10;259(7):4609-15.
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Evidence for a locus activation region: the formation of developmentally stable hypersensitive sites in globin-expressing hybrids.基因座激活区域的证据：在表达珠蛋白的杂种中形成发育稳定的超敏位点。
Nucleic Acids Res. 1987 Dec 23;15(24):10159-77. doi: 10.1093/nar/15.24.10159.
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Presence of nucleosomal repeat in the transcribed alpha globin gene of induced murine erythroleukemia cells.诱导的小鼠红白血病细胞转录的α珠蛋白基因中核小体重复序列的存在。
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Mapping of DNase I-hypersensitive sites in the upstream DNA of human embryonic epsilon-globin gene in K562 leukemia cells.K562白血病细胞中人胚胎ε-珠蛋白基因上游DNA中DNase I超敏位点的定位
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Chromatin structure of the beta-globin gene family in murine erythroleukemia cells.小鼠红白血病细胞中β-珠蛋白基因家族的染色质结构
Biochemistry. 1984 Feb 14;23(4):785-90. doi: 10.1021/bi00299a031.

引用本文的文献

1
c-Myc selectively regulates the latent period and erythroid-specific genes in murine erythroleukemia cell differentiation.c-Myc在小鼠红白血病细胞分化过程中选择性调节潜伏期和红系特异性基因。
Jpn J Cancer Res. 1993 Aug;84(8):885-92. doi: 10.1111/j.1349-7006.1993.tb02062.x.

本文引用的文献

1
Globin RNA transcription: a possible termination site and demonstration of transcriptional control correlated with altered chromatin structure.珠蛋白RNA转录：一个可能的终止位点以及与染色质结构改变相关的转录调控的证明。
Cell. 1982 Jul;29(3):887-93. doi: 10.1016/0092-8674(82)90450-0.
2
Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor.淋巴细胞有丝分裂原和血小板衍生生长因子对c-myc基因的细胞特异性调控。
Cell. 1983 Dec;35(3 Pt 2):603-10. doi: 10.1016/0092-8674(83)90092-2.
3
Induced transcription of the mouse beta-globin transcription unit in erythroleukemia cells. Time-course of induction and of changes in chromatin structure.小鼠β-珠蛋白转录单位在红白血病细胞中的诱导转录。诱导过程及染色质结构变化的时间进程。
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Expression of c-myc changes during differentiation of mouse erythroleukaemia cells.c-myc的表达在小鼠红白血病细胞分化过程中发生变化。
Nature. 1984;310(5978):592-4. doi: 10.1038/310592a0.
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Changes in gene position are accompanied by a change in time of replication.基因位置的变化伴随着复制时间的改变。
Cell. 1984 Mar;36(3):689-96. doi: 10.1016/0092-8674(84)90349-0.
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Gene expression in murine erythroleukemia cells. Transcriptional control and chromatin structure of the alpha 1-globin gene.小鼠红白血病细胞中的基因表达。α1-珠蛋白基因的转录调控与染色质结构。
J Mol Biol. 1984 Feb 5;172(4):417-36. doi: 10.1016/s0022-2836(84)80015-7.
7
Propagation of globin DNAase I-hypersensitive sites in absence of factors required for induction: a possible mechanism for determination.在缺乏诱导所需因子的情况下珠蛋白DNA酶I超敏位点的传播：一种可能的决定机制。
Cell. 1982 Aug;30(1):131-9. doi: 10.1016/0092-8674(82)90019-8.
8
Murine erythroleukemia cell differentiation: DNase I hypersensitivity and DNA methylation near the globin genes.小鼠红白血病细胞分化：珠蛋白基因附近的脱氧核糖核酸酶I超敏反应和DNA甲基化
Proc Natl Acad Sci U S A. 1982 Feb;79(4):1180-4. doi: 10.1073/pnas.79.4.1180.
9
Alterations in globin gene chromatin conformation during murine erythroleukemia cell differentiation.小鼠红白血病细胞分化过程中珠蛋白基因染色质构象的改变。
J Biol Chem. 1984 Apr 10;259(7):4609-15.
10
DNA sequences required for regulated expression of beta-globin genes in murine erythroleukemia cells.鼠红细胞白血病细胞中β-珠蛋白基因调控表达所需的DNA序列。
Cell. 1984 Aug;38(1):265-73. doi: 10.1016/0092-8674(84)90548-8.