Audet Marie-Claude, Goulet Sonia, Doré François Y
Institute of Neuroscience, Carleton University, 1125 Colonel By Drive, Ottawa, ON, Canada K1S 5B6.
Physiol Behav. 2009 Mar 2;96(3):394-8. doi: 10.1016/j.physbeh.2008.11.002. Epub 2008 Nov 13.
Phencyclidine (PCP) treatment induces social withdrawal in the rat model of schizophrenia but little is known about the qualitative adequacy of behaviors displayed during interactions. Affiliative, avoidance, and aggressive behaviors were examined in rats 20 h after the 1st, the 8th, and the 15th injection of 10 mg/kg of PCP or of a saline vehicle. PCP treatment reduced the initiation of affiliative contacts with a control congener and increased aggressive responses, in the absence of drug outcomes on time spent in social interaction. These results suggest that subchronic PCP administration in rats affects perception and appraisal of social situations as well as motivation to interact. Such pathological behaviors are consistent with the social impairments characteristic of human schizophrenia.
苯环利定（PCP）治疗可在精神分裂症大鼠模型中诱发社交退缩，但对于互动过程中所表现行为的质量是否合适却知之甚少。在首次、第八次和第十五次注射10mg/kg PCP或生理盐水载体20小时后，对大鼠的亲和行为、回避行为和攻击行为进行了检查。PCP治疗减少了与对照同类动物建立亲和接触的起始行为，并增加了攻击反应，而在社交互动所花费的时间方面没有药物效应。这些结果表明，大鼠亚慢性给予PCP会影响对社交情境的感知和评估以及互动动机。此类病理行为与人类精神分裂症的社交障碍特征相符。
