Bergenfelz A, Nordén N E, Ahrén B
Department of Surgery, Lund University, Sweden.
Clin Chim Acta. 1991 Mar 29;197(3):229-35. doi: 10.1016/0009-8981(91)90143-z.
We examined the use of an intact parathyroid hormone two-site immunoradiometric assay compared with a mid region parathyroid hormone radioimmunoassay in ethylene diamine tetraacetic acid-infusion test in 15 patients with hyperparathyroidism. During the test, plasma intact parathyroid hormone levels increased by 240 +/- 43%, whereas the plasma levels of mid molecule parathyroid hormone increased by only 65 +/- 17%, which is significantly lower (P less than 0.01). Four patients had no increase in plasma mid molecule parathyroid hormone level but still a large increase in plasma intact parathyroid hormone level (P less than 0.01). Thus, plasma measurement of intact parathyroid hormone is superior to that of mid molecule parathyroid hormone in the ethylene diamine tetraacetic acid-infusion test in patients with hyperparathyroidism.
我们在15例甲状旁腺功能亢进患者的乙二胺四乙酸输注试验中，对完整甲状旁腺激素双位点免疫放射分析与甲状旁腺激素中部区域放射免疫分析的应用进行了研究。在试验期间，血浆完整甲状旁腺激素水平升高了240±43%，而血浆甲状旁腺激素中分子水平仅升高了65±17%，显著更低（P<0.01）。4例患者血浆甲状旁腺激素中分子水平未升高，但血浆完整甲状旁腺激素水平仍大幅升高（P<0.01）。因此，在甲状旁腺功能亢进患者的乙二胺四乙酸输注试验中，血浆完整甲状旁腺激素测定优于血浆甲状旁腺激素中分子测定。
