Freund H, Maydovnik M, Laufer N, Durst A L
J Surg Oncol. 1977;9(1):93-8. doi: 10.1002/jso.2930090114.
Twenty-nine histologically verified cases of Paget's disease of the breast treated at the Hadassah University Hospital in the years 1949-1972 were followed up and analyzed. Dividing this material into two groups according to the presence or absence of a palpable breast tumor revealed significant difference in behavior and survival. Patients with a breast mass (34%) had a 50% axillary lymph node involvement and behaved as with any other ordinary breast cancer, with a 5-year survival rate of 40% and a 10-year survival rate of 33%. Patients with no palpable breast mass (66%) had only a 10.5% lymph node involvement, the 5-year survival rate being 94% and the 10-year survival rate being 91%. Delay in diagnosis seems to play no significant factor in survival rates and outcome. We believe radical mastectomy to be the treatment of choice in all cases of Paget's disease of the breast.
对1949年至1972年间在哈达萨大学医院接受治疗的29例经组织学证实的乳腺佩吉特病病例进行了随访和分析。根据是否可触及乳腺肿瘤将这些病例分为两组，结果显示其行为和生存率存在显著差异。有乳腺肿块的患者（34%）腋窝淋巴结受累率为50%，其表现与其他普通乳腺癌患者相同，5年生存率为40%，10年生存率为33%。无可触及乳腺肿块的患者（66%）淋巴结受累率仅为10.5%，5年生存率为94%，10年生存率为91%。诊断延迟似乎对生存率和预后没有显著影响。我们认为根治性乳房切除术是所有乳腺佩吉特病病例的首选治疗方法。
