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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Higuchi M, Sakanashi M

Department of Pharmacology, School of Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan.

Gen Pharmacol. 1991;22(1):183-9. doi: 10.1016/0306-3623(91)90332-z.

Nitroglycerin caused dose-dependent increases in regional myocardial contractile force (MCF) in open-chest dogs, along with dose-dependent decreases in left ventricular end-diastolic (LVEDP) and arterial pressures and an increase in plasma catecholamines level. 2. The increase in MCF could not be completely prevented by propranolol along with a slight decrease in LVEDP and no increase in heart rate, although a nifedipine-produced increase in MCF without a significant decrease in LVEDP disappeared with propranolol despite the same decrease in arterial pressure.

硝酸甘油使开胸犬局部心肌收缩力（MCF）呈剂量依赖性增加，同时左心室舒张末期压力（LVEDP）和动脉压呈剂量依赖性降低，血浆儿茶酚胺水平升高。2. 普萘洛尔不能完全阻止MCF的增加，同时LVEDP略有降低且心率未增加，尽管硝苯地平使MCF增加且LVEDP无显著降低，但在普萘洛尔作用下，尽管动脉压同样降低，这种增加却消失了。

Higuchi M, Sakanashi M

Department of Pharmacology, School of Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan.

Gen Pharmacol. 1991;22(1):183-9. doi: 10.1016/0306-3623(91)90332-z.

Nitroglycerin caused dose-dependent increases in regional myocardial contractile force (MCF) in open-chest dogs, along with dose-dependent decreases in left ventricular end-diastolic (LVEDP) and arterial pressures and an increase in plasma catecholamines level. 2. The increase in MCF could not be completely prevented by propranolol along with a slight decrease in LVEDP and no increase in heart rate, although a nifedipine-produced increase in MCF without a significant decrease in LVEDP disappeared with propranolol despite the same decrease in arterial pressure.

硝酸甘油使开胸犬局部心肌收缩力（MCF）呈剂量依赖性增加，同时左心室舒张末期压力（LVEDP）和动脉压呈剂量依赖性降低，血浆儿茶酚胺水平升高。2. 普萘洛尔不能完全阻止MCF的增加，同时LVEDP略有降低且心率未增加，尽管硝苯地平使MCF增加且LVEDP无显著降低，但在普萘洛尔作用下，尽管动脉压同样降低，这种增加却消失了。