Daniell H B
Eur J Pharmacol. 1977 Mar 7;42(1):79-84. doi: 10.1016/0014-2999(77)90193-5.
The effects of i.v. and intracoronary (i.c.) nitroglycerin, i.v. propranolol, and the combination of propranolol and nitroglycerin on myocardial oxygen consumption (MVO2) and lactate utilization were studied in situ ischemic working dog hearts. I.v. nitroglycerin reduced MVO2 9% which was associated with the peripheral vasodilatory actions of the drug. I.c. nitroglycerin which had no detectable effects on the peripheral vasculature had no significant effect on MVO2. I.v. propranolol caused an 8% reduction in MVO2 and this action was associated with a negative chronotropic and a slight negative inotropic effect. However, the combination of propranolol and nitroglycerin which was more effective than either drug alone, reduced MVO2 18% thereby indicating that the effects of the two drugs on oxygen consumption are additive. These results support the concept that the reduction of MVO2 seen with nitroglycerin is principally due to peripheral vasodilatory actions of the drug while that seen with propranolol is due to that drug's effect on the heart and the effects of the two agents are complementary.
在原位缺血工作犬心脏中，研究了静脉注射和冠状动脉内注射硝酸甘油、静脉注射普萘洛尔以及普萘洛尔与硝酸甘油联合用药对心肌耗氧量（MVO2）和乳酸利用的影响。静脉注射硝酸甘油使MVO2降低9%，这与该药物的外周血管舒张作用有关。冠状动脉内注射硝酸甘油对外周血管系统无明显影响，对MVO2也无显著影响。静脉注射普萘洛尔使MVO2降低8%，这一作用与负性变时作用和轻微的负性变力作用有关。然而，普萘洛尔与硝酸甘油联合用药比单独使用任何一种药物都更有效，使MVO2降低了18%，从而表明这两种药物对耗氧量的作用是相加的。这些结果支持了这样一种观点，即硝酸甘油使MVO2降低主要是由于该药物的外周血管舒张作用，而普萘洛尔使MVO2降低则是由于该药物对心脏的作用，且这两种药物的作用是互补的。
