Alfred Psychiatry Research Centre, The Alfred and Monash University School of Psychology, Psychiatry and Psychological Medicine, Melbourne, 3004, Australia.
World J Biol Psychiatry. 2009;10(4 Pt 3):763-71. doi: 10.1080/15622970802562793.
Investigation of neurological soft signs (NSSs) in schizophrenia may allow for a greater understanding of its underlying pathology. Motor overflow, involuntary movement occurring during voluntary movement, is a NSS thought to occur to a greater degree in schizophrenia. The aim of the current study was to replicate the only objective investigation which found enhanced motor overflow in schizophrenia and to further characterise its properties in a more systematic manner than previous research. The current study involved examining motor overflow production in 30 participants (15 with schizophrenia, 15 controls). Participants exerted 25 and 75% of their maximal force output, while overflow was monitored in the passive hand using linear variable differential transformer (LVDT) units. Patients with schizophrenia not only exhibited a significantly greater degree of motor overflow, compared to controls, they also exhibited a differential pattern of overflow production. Direct investigation of the cortical processes leading to motor overflow may provide a more complete understanding of the pathological relevance of motor overflow, and by extension NSSs, in schizophrenia.
研究精神分裂症的神经学软性体征（NSS）可以帮助我们更好地理解其潜在的病理机制。运动溢出是指在进行主动运动时出现的无意识运动，被认为在精神分裂症中更为常见。本研究旨在复制唯一一项发现精神分裂症患者运动溢出增强的客观研究，并以比以往研究更系统的方式进一步描述其特征。本研究涉及对 30 名参与者（15 名精神分裂症患者，15 名对照组）进行运动溢出产生的研究。参与者以 25%和 75%的最大力输出进行运动，同时使用线性可变差动变压器（LVDT）单元监测被动手的溢出情况。与对照组相比，精神分裂症患者不仅表现出更大程度的运动溢出，而且还表现出不同的溢出产生模式。直接研究导致运动溢出的皮质过程，可能会更全面地了解运动溢出，以及扩展到 NSS 在精神分裂症中的病理相关性。
