Maev I V, Samsonov A A, Golubev N N
Klin Med (Mosk). 2008;86(9):57-63.
Studies of the role of H. pylori (Hp) in etiopathogenesis of a number of common diseases of the upper gastrointestinal tract changed traditional approaches to their management with emphasis on antibiotic therapy. Positive effect of Hp eradication was confirmed in numerous randomized clinical studies. Bismuth-containing drugs have been used for a long time to treat gastrointestinal disorders. To-day, bismuth tri-potassium di-citrate (de---nol) is considered to be an optimal tool for different schemes of eradication therapy (triple and quadruple therapy of the first and second lines) and recommended to improve its efficiency by overcoming resistance of Hp to antibiotics. The overall efficacy of anti-helicobacterial therapy using bismuth tri-potassium di-citrate amounts to 81-98%. This compound has cytoprotective effect on gastric and duodenal mucosa, besides antibacterial action. All these properties characterize de-nol as a single universal preparation for the treatment of erosive ulcers in the gastrointestinal tract.
幽门螺杆菌（Hp）在上消化道多种常见疾病病因学中作用的研究改变了传统的治疗方法，重点在于抗生素治疗。大量随机临床研究证实了根除Hp的积极效果。含铋药物长期以来一直用于治疗胃肠道疾病。如今，枸橼酸铋钾（得乐）被认为是不同根除治疗方案（一线和二线的三联和四联疗法）的最佳药物，并建议通过克服Hp对抗生素的耐药性来提高其疗效。使用枸橼酸铋钾的抗幽门螺杆菌治疗的总体疗效为81% - 98%。该化合物除了具有抗菌作用外，对胃和十二指肠黏膜还有细胞保护作用。所有这些特性使得乐成为治疗胃肠道糜烂性溃疡的单一通用制剂。
