Luzanova I S, Pletneva T V, Maksimova T V, Salomatin E M, Lutskiĭ Ia M
Sud Med Ekspert. 2008 Sep-Oct;51(5):41-3.
The problem of poisoning with thallium-containing substances continues to be of current concern. According to the Bureau of Forensic Medical Examination, Moscow, specimens of biological materials from more than 20 victims of such poisoning were delivered for analysis in 2006. The total number of thallium poisoning episodes during the period since 1996 exceeded 50. Materials for thallium determination in biological fluids (human blood and urine) using flame atomic absorption spectrometry were prepared by dry mineralization of accurately weighed samples; acidic solutions of the products of mineralization were used for analysis. Due to peculiar kinetic features of thallium ion absorption in the gastro-intestinal tract, blood could not be used as a biological marker of poisoning. The level of thallium in urine samples was found to vary from 1.00 to 4,600 mcg/l (with the estimation of confidence intervals in each case). Results of chemical analysis correlated with pathological symptoms derived from the patients' discharge summaries and literature reports on dose-effect relationships. Based on these findings, practically all the examined cases were characterized as severe acute poisoning.
含铊物质中毒问题仍然是当前令人关注的问题。据莫斯科法医鉴定局称，2006年有20多名此类中毒受害者的生物材料样本被送去分析。自1996年以来铊中毒事件的总数超过了50起。采用火焰原子吸收光谱法测定生物体液（人血和尿液）中铊的材料，是通过对精确称重的样品进行干式矿化制备的；矿化产物的酸性溶液用于分析。由于铊离子在胃肠道吸收的特殊动力学特性，血液不能用作中毒的生物标志物。尿液样本中铊的含量在1.00至4600微克/升之间（每种情况均估计了置信区间）。化学分析结果与患者出院小结中的病理症状以及剂量效应关系的文献报道相关。基于这些发现，几乎所有检查的病例都被判定为严重急性中毒。
