Kobori Go, Yamada Hitosi, Higashi Yoshito
The Department of Urology, Ijinnkai Takeda General Hospital.
Hinyokika Kiyo. 2008 Oct;54(10):657-9.
A 71-year-old woman was admitted with fever up and weight loss. Abdominal computed tomography (CT) revealed right renal tumor 7 cm in diameter and inferior vena caval thrombus and multiple lymph node metastases and lung metastases. Transabdominal right nephrectomy and thrombectomy was performed and pathological examination was renal cell carcinoma (clear cell carcinoma, G3, INFbeta, v (+), pT3b, pN2) with adrenal invasion and lymph node metastases. She received 600 x 10(4) IU/day of interferon alpha (IFN-alpha) intramuscularly 3 times a week for 16 weeks from the 20th post-operative day. The disease showed progression and liver metastases 5 cm in diameter appeared. Then she received 140 x 10(4) JRU/day of IL-2 (div) 5 times a week for 4 weeks. CT showed a complete response on lung metastases and lymph node metastases and marked decrease of liver metastases after the first course of IL-2. After the second course, the liver mass remained 2 cm in diameter and then radiofrequency ablation (RFA) under CT was performed. CT after RFA showed a low density area at the liver tumor without enhancement. About five years after the operation, she is alive without evidence of disease.
一名71岁女性因发热和体重减轻入院。腹部计算机断层扫描（CT）显示右肾有一个直径7厘米的肿瘤，伴有下腔静脉血栓形成、多处淋巴结转移和肺转移。行经腹右肾切除术和血栓切除术，病理检查为肾细胞癌（透明细胞癌，G3，INFβ，v（+），pT3b，pN2），伴有肾上腺侵犯和淋巴结转移。自术后第20天起，她每周接受3次干扰素α（IFN-α）肌肉注射，剂量为600×10⁴IU/天，共16周。疾病出现进展，出现直径5厘米的肝转移。然后她每周接受5次IL-2静脉注射，剂量为140×10⁴JRU/天，共4周。CT显示在IL-2的第一个疗程后，肺转移和淋巴结转移完全缓解，肝转移明显缩小。第二个疗程后，肝脏肿块直径仍为2厘米，随后在CT引导下进行射频消融（RFA）。RFA后CT显示肝脏肿瘤处有一个低密度区，无强化。术后约五年，她存活且无疾病证据。
