Yabe Ichiro, Sato Kazunori, Soma Hiroyuki, Sasaki Hidenao
Department of Neurology, Hokkaido University Graduate School of Medicine.
Rinsho Shinkeigaku. 2008 Sep;48(9):640-5. doi: 10.5692/clinicalneurol.48.640.
To determine the frequency of cerebellar ataxia patients with autoantibodies for Hashimoto's disease, we analyzed 68 patients who were examined serum test for autoantibodies of Hashimoto disease among 178 cerebellar ataxia patients who visited our neurology clinic from January 2005 until December 2007. In these 68 patients, 8 had autoantibodies for Hashimoto's disease. Five of these 8 patients were diagnosed with hereditary spinocerebellar ataxia by genetic analysis. Moreover, one patient was diagnosed with probable multiple system atrophy by neurological examination. Cerebellar ataxic disease of known causes was ruled out for the remaining two cases; they were euthyroid and their cerebellar ataxia was slowly progressive and were diagnosed with cortical cerebellar atrophy. Although Hashimoto's disease may associate with cerebellar ataxia because cortical cerebellar atrophy is a heterogeneous condition, this association is not clear at present.
为了确定患有自身免疫性桥本氏病抗体的小脑共济失调患者的比例，我们分析了2005年1月至2007年12月期间到我院神经科就诊的178例小脑共济失调患者，其中68例接受了桥本氏病自身抗体血清检测。在这68例患者中，8例患有桥本氏病自身抗体。通过基因分析，这8例患者中有5例被诊断为遗传性脊髓小脑共济失调。此外，1例患者经神经检查被诊断为可能的多系统萎缩。其余2例排除了已知病因的小脑共济失调疾病；他们甲状腺功能正常，小脑共济失调呈缓慢进展，被诊断为皮质小脑萎缩。尽管桥本氏病可能与小脑共济失调有关，因为皮质小脑萎缩是一种异质性疾病，但目前这种关联尚不清楚。
