[Serum lactic dehydrogenase isoenzymes in metastatic and primary liver carcinoma (author's transl)].

Serum LDH isoenzymes were comparatively evaluated in experimental and human liver carcinoma. In our experimental studies, LDH4 increased in AH 66 F metastatic hepatic cancer, but DAB hepatic cancer showed a significant increase of LDH5. In clinical studies, LDH4 and LDH5 increased significantly in metastatic liver carcinoma, and 15 (79%) out of 19 cases showed higher values of LDH4. In primary liver carcinoma LDH5 increased significantly, and 12 (92%) out of 13 cases showed a higher LDH5. Therefore, analyses of serum LDH isoenzymes would aid in differential diagnosis of metastatic and primary liver carcinoma.