Polterauer P, Rauhs R, Puxkandl H
Wien Klin Wochenschr. 1981 Apr 3;93(7):227-30.
Serum alpha-1-fetoprotein (AFP) and serum lactic dehydrogenase isoenzymes (LDH I-V) were evaluated in healthy subjects as well as in 10 patients with primary liver carcinoma, in 10 patients with metastatic liver cancer and in 10 patients with cirrhosis of the liver. The diagnosis was established histologically in all cases. The upper limit of the normal AFP range was 9 ng/ml. Four out of all the patients with hepatocellular or cholangiocellular carcinomas had normal AFP values, 3 showed slightly increased AFP values, whilst a serum AFP concentration exceeding 174 ng/ml - limit which is statistically highly suggestive of hepatoma - was found in only 3 patients. Three out of the patients with metastatic liver cancer and 3 with cirrhosis showed moderately increased AFP values. In primary liver cancer LDH V is increased significantly and 8 out of all patients showed higher values of LDH V than LDH IV. By contrast, patients with metastatic liver cancer had significantly increased LDH IV, which was higher than LDH V in 9 out of all cases. Cirrhotics showed normal LDH isoenzymes. Combining these results, a definitive diagnosis could be made in 9 patients with primary carcinoma of the liver and in 9 patients with metastatic liver cancer.
对健康受试者以及10例原发性肝癌患者、10例转移性肝癌患者和10例肝硬化患者的血清甲胎蛋白（AFP）和血清乳酸脱氢酶同工酶（LDH I-V）进行了评估。所有病例均经组织学确诊。正常AFP范围的上限为9 ng/ml。在所有肝细胞癌或胆管细胞癌患者中，4例AFP值正常，3例AFP值略有升高，而只有3例患者的血清AFP浓度超过174 ng/ml（该水平在统计学上高度提示肝癌）。3例转移性肝癌患者和3例肝硬化患者的AFP值中度升高。在原发性肝癌中，LDH V显著升高，所有患者中有8例LDH V值高于LDH IV。相比之下，转移性肝癌患者的LDH IV显著升高，所有病例中有9例LDH IV高于LDH V。肝硬化患者的LDH同工酶正常。综合这些结果，9例原发性肝癌患者和9例转移性肝癌患者得以确诊。
