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HIV感染中CCR7配体CCL19和CCL21水平升高：与病毒载量、疾病进展及高效抗逆转录病毒治疗反应的相关性

Enhanced levels of the CCR7 ligands CCL19 and CCL21 in HIV infection: correlation with viral load, disease progression and response to highly active antiretroviral therapy.

作者信息

Damås Jan K, Landrø Linn, Fevang Børre, Heggelund Lars, Frøland Stig S, Aukrust Pål

机构信息

Department of Infectious Diseases, St Olavs Hospital, Olav Kyrres gt 17, 7006 Trondheim, Norway.

出版信息

AIDS. 2009 Jan 2;23(1):135-8. doi: 10.1097/QAD.0b013e32831cf595.

DOI:10.1097/QAD.0b013e32831cf595
PMID:19050397
Abstract

The CCR7 ligands, CCL19 and CCL21, coordinate lymph node homing of naive and central memory T cells. In untreated HIV-infected patients, serum levels of CCL19 and CCL21 showed a biphasic pattern during progression; a marked increase was followed by a decline in patients with advanced immunodeficiency. During highly active antiretroviral therapy, a decrease in CCL19/CCL21 levels was restricted to virologic responders. We suggest that dysregulation of CCR7 ligands may play an important role in progression of HIV infection.

摘要

CCR7配体CCL19和CCL21协调初始T细胞和中枢记忆T细胞归巢至淋巴结。在未经治疗的HIV感染患者中，CCL19和CCL21的血清水平在疾病进展过程中呈双相模式；在免疫缺陷严重的患者中，先是显著升高，随后下降。在高效抗逆转录病毒治疗期间，CCL19/CCL21水平的降低仅限于病毒学应答者。我们认为，CCR7配体失调可能在HIV感染进展中起重要作用。

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