Bhadriraju Satish, Kemp Carlton R, Cheruvu Mani, Bhadriraju Srinivas
Internal Medicine Department, Memorial University Medical Center, Savannah, Georgia 31404, USA.
Crit Pathw Cardiol. 2008 Dec;7(4):248-53. doi: 10.1097/HPC.0b013e31818ae644.
Global risk assessment is the standard of care for coronary artery disease management. In this setting, sleep apnea syndrome, which includes obstructive sleep apnea and central sleep apnea, is being increasingly recognized as a potentially modifiable risk factor for coronary artery disease. Emerging evidence points toward a cause and effect relationship between sleep apnea syndrome and medical conditions like insulin resistance, hypertension, heart failure, and myocardial ischemia. The effects of sleep apnea on coronary artery disease can be independent of many traditional risk factors. Continuous positive airway pressure has been shown to decrease inflammatory markers that are elevated in sleep apnea syndrome. Well-designed randomized controlled clinical trials are needed to better establish the role of sleep apnea in the genesis and progression of coronary artery disease.
全球风险评估是冠心病管理的护理标准。在这种情况下，包括阻塞性睡眠呼吸暂停和中枢性睡眠呼吸暂停在内的睡眠呼吸暂停综合征越来越被认为是冠心病潜在的可改变风险因素。新出现的证据表明睡眠呼吸暂停综合征与胰岛素抵抗、高血压、心力衰竭和心肌缺血等疾病之间存在因果关系。睡眠呼吸暂停对冠心病的影响可能独立于许多传统风险因素。持续气道正压通气已被证明可降低睡眠呼吸暂停综合征中升高的炎症标志物。需要精心设计的随机对照临床试验，以更好地确定睡眠呼吸暂停在冠心病发生和发展中的作用。
