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特定的海马体损伤表明，在突触后和苔藓纤维上均存在与ATP敏感性钾通道相关的磺脲类结合位点。

Specific hippocampal lesions indicate the presence of sulfonylurea binding sites associated to ATP-sensitive K+ channels both post-synaptically and on mossy fibers.

作者信息

Mourre C, Widmann C, Lazdunski M

机构信息

Institut de Pharmacologie moléculaire et cellulaire, Valbonne, France.

出版信息

Brain Res. 1991 Feb 1;540(1-2):340-4. doi: 10.1016/0006-8993(91)90533-2.

DOI:10.1016/0006-8993(91)90533-2
PMID:1905175
Abstract

The density of glibenclamide (GB) binding sites decreases considerably in the dentate gyrus (greater than 80%), the CA1 field (approximately 75%) and the stratum lucidum of CA3 field (approximately 70%) after intradentate colchicine injections in rat hippocampus. The density of GB receptors is unchanged in kainic acid damaged hippocampus. These data show that GB binding sites associated to adenosine triphosphate-sensitive K+ channels are mainly located in granular cells in both pre- and post-synaptic positions. They are present in mossy fibers.

摘要

在大鼠海马齿状回内注射秋水仙碱后，格列本脲（GB）结合位点的密度在齿状回（超过80%）、CA1区（约75%）和CA3区透明层（约70%）显著降低。在 kainic 酸损伤的海马中，GB 受体的密度没有变化。这些数据表明，与三磷酸腺苷敏感钾通道相关的 GB 结合位点主要位于突触前和突触后位置的颗粒细胞中。它们存在于苔藓纤维中。

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Specific hippocampal lesions indicate the presence of sulfonylurea binding sites associated to ATP-sensitive K+ channels both post-synaptically and on mossy fibers.特定的海马体损伤表明，在突触后和苔藓纤维上均存在与ATP敏感性钾通道相关的磺脲类结合位点。
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