Garikapaty Venkata P S, Feyerharm Robert, Zhu Baoping
Section of Epidemiology for Public Health Practices, Division of Community and Public Health, Missouri Department of Health and Senior Services, Jefferson City, USA.
Mo Med. 2008 Nov-Dec;105(6):504-9.
Periconceptional folic acid consumption significantly reduces the risk for neural tube defects. The purpose of this study was to identify the risk factors for poor periconceptional folic acid supplementation among Missouri women. Sixty-five percent of Missouri women reported not taking periconceptional multivitamins regularly. Unintended pregnancy (aOR = 0.49), maternal adolescent age (aOR = 0.44) and smoking before pregnancy (aOR = 0.53) were significantly associated with poor periconceptional multivitamin use. Folic acid interventions targeting specific sub-groups of women are needed in Missouri.
孕期前叶酸摄入可显著降低神经管缺陷风险。本研究旨在确定密苏里州女性孕期前叶酸补充不足的风险因素。65%的密苏里州女性报告未定期服用孕期前复合维生素。意外怀孕（调整后比值比[aOR]=0.49）、母亲为青少年（aOR=0.44）以及孕前吸烟（aOR=0.53）与孕期前复合维生素使用不足显著相关。密苏里州需要针对特定女性亚组开展叶酸干预措施。
