Kluge Michael, Uhr Manfred, Bleninger Philipp, Yassouridis Alexander, Steiger Axel
Max-Planck Institute of Psychiatry, Munich, Germany.
Clin Endocrinol (Oxf). 2009 Jun;70(6):920-3. doi: 10.1111/j.1365-2265.2008.03440.x. Epub 2008 Sep 29.
Ghrelin decreases the secretion of LH probably by suppressing the release of hypothalamic GnRH. So far however, there is no evidence that ghrelin affects also the secretion of FSH in humans, the other gonadotrophin regulated by GnRH.
Our objective was to study the effect of ghrelin on secretion of FSH in humans. DESIGN/STUDY SUBJECTS: Nocturnal (20:00-07:00 h) secretion profiles of FSH were measured in 10 healthy males (25.3 +/- 3.2 years) twice, receiving 50 microg ghrelin or placebo at 22:00, 23:00, 24:00, and 01:00 h, in this single-blind, randomized, cross-over study.
Mean FSH plasma levels were significantly (P < 0.05) lower with ghrelin than placebo between 01:00 and 02:20. Consistently, a significant decrease from baseline was only observed in the ghrelin but not in the placebo condition.
This study provides first evidence that ghrelin suppresses the secretion of FSH in humans.
胃饥饿素可能通过抑制下丘脑促性腺激素释放激素（GnRH）的释放来降低促黄体生成素（LH）的分泌。然而，迄今为止，尚无证据表明胃饥饿素也会影响人类促卵泡生成素（FSH）的分泌，FSH是另一种受GnRH调节的促性腺激素。
我们的目的是研究胃饥饿素对人类FSH分泌的影响。设计/研究对象：在这项单盲、随机、交叉研究中，对10名健康男性（25.3±3.2岁）进行了两次促卵泡生成素夜间（20:00 - 07:00）分泌情况的测量，在22:00、23:00、24:00和01:00时分别给予50微克胃饥饿素或安慰剂。
在01:00至02:20期间，胃饥饿素组的促卵泡生成素血浆平均水平显著低于安慰剂组（P < 0.05）。一致的是，仅在胃饥饿素组观察到与基线相比有显著下降，而安慰剂组未观察到这种情况。
本研究首次提供了胃饥饿素抑制人类促卵泡生成素分泌的证据。
