Kluge Michael, Schüssler Petra, Uhr Manfred, Yassouridis Alexander, Steiger Axel
Max-Planck Institute of Psychiatry, Kraepelinstrasse 2-10, 80804 Munich, Germany.
J Clin Endocrinol Metab. 2007 Aug;92(8):3202-5. doi: 10.1210/jc.2007-0593. Epub 2007 Jun 5.
Ghrelin affects the hypothalamic-pituitary-gonadal axis in various nonhuman mammalians, predominantly by suppressing secretion of LH. However, for humans, no such evidence exists.
Our objective was to study the effect of ghrelin on secretion of LH and testosterone in humans.
DESIGN, PARTICIPANTS, AND INTERVENTION: Nocturnal (2000-0700 h) secretion profiles of LH and testosterone were determined in 10 healthy males (25.7 +/- 3.0 yr) twice, receiving 50 microg ghrelin or placebo at 2200, 2300, 2400, and 0100 h, in this single-blind, randomized, cross-over study.
Ghrelin was associated with significantly (P < 0.05) lower mean plasma levels of both LH (2340-0200 h) and testosterone (0040-0300 h) than placebo. LH peak levels of the pulse after first administration of ghrelin/placebo were significantly (P = 0.014) smaller in the ghrelin (2.98 +/- 1.34 mIU/ml) than in the placebo condition (4.37 +/- 1.09 mIU/ml). In addition, the interval between this and the preceding peak was significantly (P = 0.010) longer in the ghrelin (255.8 +/- 79.1 min) than in the placebo condition (190.8 +/- 51.0 min). Significantly (P = 0.005) more LH pulses occurred with placebo (3.2 +/- 0.75) than ghrelin (2.6 +/- 0.7) subsequent to ghrelin/placebo administration.
Ghrelin caused both a delay and suppression of the amplitude of LH pulses. These findings are in accordance with those in nonhuman mammalians.
胃饥饿素在多种非人类哺乳动物中影响下丘脑 - 垂体 - 性腺轴，主要是通过抑制促黄体生成素（LH）的分泌。然而，在人类中尚无此类证据。
我们的目的是研究胃饥饿素对人类促黄体生成素（LH）和睾酮分泌的影响。
设计、参与者和干预措施：在这项单盲、随机、交叉研究中，对10名健康男性（25.7±3.0岁）进行了两次促黄体生成素（LH）和睾酮夜间（20:00 - 07:00）分泌情况的测定，在22:00、23:00、24:00和01:00时分别给予50微克胃饥饿素或安慰剂。
与安慰剂相比，胃饥饿素导致促黄体生成素（LH，23:40 - 02:00时）和睾酮（00:40 - 03:00时）的平均血浆水平显著降低（P < 0.05）。首次给予胃饥饿素/安慰剂后，胃饥饿素组（2.98±1.34 mIU/ml）促黄体生成素（LH）脉冲的峰值水平显著低于安慰剂组（4.37±1.09 mIU/ml）（P = 0.014）。此外，胃饥饿素组该峰值与前一个峰值之间的间隔时间（255.8±79.1分钟）显著长于安慰剂组（190.8±51.0分钟）（P = 0.010）。给予胃饥饿素/安慰剂后，安慰剂组（3.2±0.75）出现的促黄体生成素（LH）脉冲显著多于胃饥饿素组（2.6±0.7）（P = 0.005）。
胃饥饿素导致促黄体生成素（LH）脉冲延迟且幅度受到抑制。这些发现与非人类哺乳动物的情况一致。
