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一种治疗铅中毒的口服疗法。

An oral treatment for lead toxicity.

作者信息

Thomas P S, Ashton C

机构信息

Northwick Park Hospital, Harrow, Middlesex, UK.

出版信息

Postgrad Med J. 1991 Jan;67(783):63-5. doi: 10.1136/pgmj.67.783.63.

DOI:10.1136/pgmj.67.783.63
PMID:1905404
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2398946/
Abstract

Chronic lead poisoning has traditionally been treated by parenteral agents. We present a case where a comparison of ethylene diaminetetra-acetic acid was made with 2,3-dimethyl succinic acid (DMSA) which has the advantage of oral administration associated with little toxicity and appeared to be at least as efficacious.

摘要

传统上,慢性铅中毒采用肠胃外给药进行治疗。我们报告了一例病例,该病例对乙二胺四乙酸与2,3-二甲基琥珀酸(DMSA)进行了比较,DMSA具有口服优势,毒性小,且疗效似乎至少相当。

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引用本文的文献

1
An oral treatment for lead toxicity.一种治疗铅中毒的口服疗法。
Postgrad Med J. 1991 Oct;67(792):953. doi: 10.1136/pgmj.67.792.953.

本文引用的文献

1
DMSA and DMPS--water soluble antidotes for heavy metal poisoning.二巯基丁二酸和二巯基丙磺酸钠——重金属中毒的水溶性解毒剂。
Annu Rev Pharmacol Toxicol. 1983;23:193-215. doi: 10.1146/annurev.pa.23.040183.001205.
2
[Lead poisoning treated with 2,3-dimercaptosuccinic acid].
Presse Med. 1984 Oct 13;13(36):2209.
3
Chelating therapy with Na-DMS in occupational lead and mercury intoxications.
Chin Med J. 1965 Jul;84(7):437-9.
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Comparative mobilization of lead by chelating agents.螯合剂对铅的相对动员作用。
Toxicology. 1988 Dec 30;53(2-3):277-88. doi: 10.1016/0300-483x(88)90220-x.
5
Mobilization and redistribution of lead over the course of calcium disodium ethylenediamine tetraacetate chelation therapy.在乙二胺四乙酸二钠钙螯合治疗过程中铅的动员与再分布
J Pharmacol Exp Ther. 1987 Dec;243(3):804-13.
6
Meso-2,3-dimercaptosuccinic acid in the diagnosis and treatment of lead poisoning.
J Toxicol Clin Toxicol. 1987;25(1-2):39-51. doi: 10.3109/15563658708992612.
7
2,3-Dimercaptosuccinic acid as an antidote for lead intoxication.
Clin Pharmacol Ther. 1985 Apr;37(4):431-8. doi: 10.1038/clpt.1985.67.
8
2,3-Dimercaptosuccinic acid treatment of heavy metal poisoning in humans.2,3-二巯基丁二酸对人类重金属中毒的治疗作用。
Med Toxicol Adverse Drug Exp. 1988 Nov-Dec;3(6):499-504. doi: 10.1007/BF03259898.
9
Dose-response study of oral 2,3-dimercaptosuccinic acid in children with elevated blood lead concentrations.
J Pediatr. 1988 Oct;113(4):751-7. doi: 10.1016/s0022-3476(88)80396-2.
10
Mobilization of lead over the course of DMSA chelation therapy and long-term efficacy.二巯基丁二酸螯合疗法过程中铅的动员及长期疗效。
J Pharmacol Exp Ther. 1988 Jul;246(1):84-91.